Reversal of morphine antinociceptive tolerance and dependence by the acute supraspinal inhibition of Ca(2+)/calmodulin-dependent protein kinase II

The Journal of Pharmacology and Experimental Therapeutics
Lei TangZaijie Jim Wang

Abstract

Previous studies have suggested that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) can modulate opioid tolerance and dependence via its action on learning and memory. In this study, we examined whether CaMKII could directly regulate opioid tolerance and dependence. CaMKII activity was increased after the treatment with morphine (100 mg/kg s.c. or 75 mg s.c. of morphine/pellet/mouse); the effect exhibited a temporal correction with the development of opioid tolerance and dependence. In mice treated with morphine (100 mg/kg s.c.), morphine tolerance and dependence developed in 2 to 6 h. An acute supraspinal administration of KN93 [2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)], a CaMKII inhibitor, was able to dose-dependently reverse the already-established antinociceptive tolerance to morphine (p < 0.001 for 15-30 nmol; not significant for 5 nmol). KN92 [2-[N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine] (30 nmol i.c.v.), a kinase-inactive analog of KN93, did not affect opioid tolerance. Neither KN92 nor KN93 affected basal nociception or acute morphine antinociception (1-10 nmol i.c.v.). Likewise, dependence on morphine was abolished by ...Continue Reading

References

Oct 29, 1993·Brain Research·H B Gutstein, K A Trujillo
Oct 3, 2001·The American Journal on Addictions·E J Nestler
Apr 5, 2002·The Biochemical Journal·Andy Hudmon, Howard Schulman
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·J Mark QuillanWolfgang Sadée
Mar 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Olga ValverdeRafael Maldonado

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Citations

May 30, 2009·The Journal of Pharmacology and Experimental Therapeutics·Yan ChenZaijie Jim Wang
Mar 26, 2011·The Journal of Pharmacology and Experimental Therapeutics·Cheng YangZaijie Jim Wang
Aug 18, 2006·Molecular Pharmacology·Shuang LiCharles Chavkin
Jan 9, 2008·PLoS Computational Biology·Chuan-Yun LiLiping Wei
Jul 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ying HeZaijie Jim Wang
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan ChenZaijie Jim Wang
Oct 4, 2011·Journal of Pharmacy & Bioallied Sciences·Eric Woode, Wonder K M Abotsi
Mar 29, 2014·Behavioural Brain Research·Mehdi KadivarMohammad-Reza Zarrindast
Oct 8, 2014·Translational Psychiatry·A C EastonC P Müller
Dec 18, 2015·Trends in Pharmacological Sciences·Christian P MüllerK Peter Giese
Jul 13, 2006·Life Sciences·Zaijie Jim Wang, Lili X Wang
Jul 28, 2016·The Journal of Pharmacology and Experimental Therapeutics·Zhen LiFang Luo
Jan 8, 2008·The Journal of Pharmacology and Experimental Therapeutics·Fang LuoZaijie Jim Wang
Dec 18, 2014·The Journal of Pharmacology and Experimental Therapeutics·Xiaoyu HuZaijie Jim Wang
Aug 12, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jan Rodriguez ParkitnaRyszard Przewlocki
Dec 7, 2007·Anesthesiology Clinics·Gary McCleane, Howard S Smith

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