PMID: 1370765Jan 1, 1992Paper

Reversal of multidrug resistance by an immunosuppressive agent FK-506

Cancer Chemotherapy and Pharmacology
M NaitoT Tsuruo

Abstract

FK-506, a novel immunosuppressive agent, was examined for its reversing effect on multidrug-resistant tumor cells. FK-506 at 3 microM completely reversed the resistance against vincristine (VCR) in vitro in VCR-resistant mouse leukemia P388 cells (P388/VCR). FK-506 also enhanced the cytotoxicity of VCR in Adriamycin(ADM)-resistant human ovarian cancer A2780 cells (AD10) and ADM-resistant human myelogenous leukemia K562 cells (K562/ADM) in vitro. FK-506 was also effective in modulating sensitivity to ADM in AD10 cells in vitro. FK-506 enhanced the chemotherapeutic effect of VCR in P388/VCR-bearing mice. When 20 mg/kg FK-506 was combined with 200 micrograms/kg VCR, a T/C value of 151% was obtained. Under the protocol used in this study, FK-506 was more potent than cyclosporin A (CsA) and verapamil. FK-506 inhibited [3H]azidopine binding to P-glycoprotein efficiently. The binding of VCR to K562/ADM plasma membrane was inhibited by FK-506 as effectively as by CsA. Moreover, the accumulation of VCR in AD10 cells was increased by FK-506 as efficiently as that of CsA and verapamil. These results indicate that FK-506 directly interacts with P-glycoprotein like CsA and verapamil, inhibits the active efflux of vincristine from resistant ...Continue Reading

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Citations

Jan 1, 1993·Cytotechnology·J M Ford, W N Hait
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·M Naito, T Tsuruo
Jan 1, 1993·Mutation Research·L R Ferguson, B C Baguley
Jan 28, 2004·European Journal of Pharmacology·Emiko AsakuraTakaaki Hasegawa
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Nov 21, 2001·Japanese Journal of Cancer Research : Gann·K KurosawaT Tsuruo
Feb 1, 1996·Japanese Journal of Cancer Research : Gann·T WatanabeT Tsuruo
Oct 1, 1995·Journal of Pharmaceutical Sciences·E NakashimaF Ichimura
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