Reversal of multiorgan system dysfunction in sickle cell disease with plasma exchange

Acta Anaesthesiologica Scandinavica
E J Geigel, C W Francis

Abstract

A 23-year-old man with sickle cell anemia and multiorgan system dysfunction was treated with plasma exchange during a sickle cell crisis. The patient failed to respond to conventional treatment including hydration, blood transfusions, broad spectrum antibiotics, supplemental oxygen, and analgesics. The clinical picture resembled thrombotic thrombocytopenic purpura (TTP), and the patient responded dramatically to plasma exchange with reversal of a rapidly deteriorating clinical state. This case illustrates possible similarities in the pathophysiology of TTP and sickle cell crisis, and the value of plasma exchange in related critical disease states.

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Citations

Dec 12, 2012·Annals of Hematology·Durjoy K ShomeNeelam Malik
Nov 5, 1999·Current Opinion in Hematology·W F Reed, E P Vichinsky
Jul 22, 2009·The Journal of Clinical Investigation·Gregory J Kato
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Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fasika M Tedla, Eli A Friedman

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