Reversal of pathophysiologic changes with long-term lisinopril treatment in isolated systolic hypertension

Journal of Cardiovascular Pharmacology
W F HeesenK I Lie

Abstract

The purpose of this study was to evaluate in a prospective, double-blind, placebo-controlled study the effect of long-term (2-year) lisinopril treatment on cardiovascular end-organ damage in patients with previously untreated isolated systolic hypertension (ISH). All patients with ISH were derived from a population screening program. End-organ damage measurements, done initially and after 6 and 24 months of treatment, included measurements of aortic distensibility and echocardiographic left ventricular mass index (LVMI) and diastolic function. Blood pressure was measured by office and ambulatory measurements. Of the 97 subjects with ISH selected from the screening, 62 (30 lisinopril) completed the study according to protocol. Office blood pressure decreased in both groups, but ambulatory results significantly decreased with lisinopril-treatment only. Aortic distensibility increased significantly with lisinopril, as opposed to a decrease in placebo-treated subjects. The main effect of increased distensibility occurred between 6 and 24 months, whereas ambulatory blood pressure changed mainly in the first 6 months of treatment. LVMI decreased in both treatment groups, with a significantly higher reduction in lisinopril-treated sub...Continue Reading

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Citations

Mar 2, 2012·Cardiology·Konstantinos Dean BoudoulasHarisios Boudoulas
Jan 27, 2005·Nursing & Health Sciences·Julia Wong, Shirley Wong
Jul 18, 2003·The American Journal of Medicine·Arnfried U KlingbeilRoland E Schmieder
Apr 2, 2011·Journal of the American College of Cardiology·João L CavalcanteMouaz H Al-Mallah
Jul 17, 2012·International Journal of Cardiology·Pierluigi CostanzoPasquale Perrone-Filardi
Mar 29, 2008·American Journal of Hypertension·Cesare CuspidiGiuseppe Mancia
Jan 10, 2018·Hypertension·Kristen L NowakDouglas R Seals
Jun 27, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Isabel N SchellingerUwe Raaz

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