Reversal of profound rocuronium block monitored in three muscle groups with sugammadex in ponies

British Journal of Anaesthesia
M MosingJ M Hunter

Abstract

This clinical study evaluated the speed of reversal of profound rocuronium block in ponies using sugammadex and investigated the differences in onset and recovery from block in three different muscle groups. Anaesthesia was induced and maintained with isoflurane in oxygen 100% in eight ponies. Neuromuscular monitoring was performed at each site using acceleromyography: in the extensor muscles of the pelvic limb (peroneal nerve) and thoracic limb (radial nerve), and in the orbicularis oris muscle (OOM; facial nerve). Rocuronium 0.6 mg kg(-1) i.v. was administered, followed 5 min later by sugammadex 4 mg kg(-1) i.v. Onset time (onsetROC), maximum block, and time to recovery of the train-of-four ratio to 0.9 (TOFR=0.9) were recorded. The differences between monitored sites were compared using one-way anova followed by a post hoc Dunn's test. Onset of ROC was significantly delayed in OOM compared with both limbs [pelvic limb, thoracic limb, and OOM: 43.1 (sd 16.9), 50.6 (15.9), and 204.4 (35.8) s, respectively; P<0.001]. Complete block was achieved in the pelvic and thoracic limbs, but in none of the eight ponies in the OOM [mean T1=15.3 (9.4)%; range: 7-36%]. No differences were observed between muscle sites in recovery to TOFR=0....Continue Reading

References

May 1, 1995·Equine Veterinary Journal·G M JohnstonJ L Wood
Nov 1, 1993·British Journal of Anaesthesia·C Ibebunjo, L W Hall
Feb 24, 2007·Veterinary Anaesthesia and Analgesia·Ulrike AuerMartina Mosing
Feb 20, 2009·Anesthesia and Analgesia·Paul F WhiteM E Hudson

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Citations

Feb 15, 2012·Regional Anesthesia and Pain Medicine·Matthew C WylieCharles B Berde
Mar 29, 2014·Anesthesiology Research and Practice·Shigeaki OtomoHiroshi Iwasaki
Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Manuel Martin-Flores
May 29, 2013·Veterinary Anaesthesia and Analgesia·Charlotte MarlyMartina Mosing
Feb 4, 2011·Acta Anaesthesiologica Scandinavica·T Suzuki
Jun 11, 2015·Veterinary Anaesthesia and Analgesia·Ronald S JonesMartina Mosing

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