PMID: 2505628Jul 1, 1989Paper

Reversal of prolonged sedation using flumazenil in critically ill patients

Anaesthesia
A Bodenham, G R Park

Abstract

Thirteen critically ill patients received flumazenil after multiple doses, or an infusion, of midazolam was used as part of a sedation regimen to facilitate intensive care. All patients remained excessively sedated after the midazolam was stopped for 6 hours or longer. An improvement in conscious level occurred in eight patients (61%). In four of these eight patients, the duration of action of flumazenil necessitated its continued administration by an infusion to maintain the improvement in conscious level. The dose of flumazenil required each hour was less than estimated previously; this indicates that it may be subjected to similar alterations of elimination as those described for midazolam. Flumazenil appears to be a useful drug for the reversal of prolonged benzodiazepine sedation but repeated bolus doses or an infusion are needed if significant accumulation of benzodiazepines has occurred.

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Citations

Jan 1, 1996·Irish Journal of Medical Science·A TaylorJ R McCarthy
Dec 1, 1995·Critical Care Medicine·M A MirskiD F Hanley
May 1, 1997·Journal of Clinical Nursing·E C Carr, V J Thomas
Jan 1, 1990·Acta Anaesthesiologica Scandinavica. Supplementum·J G Whitwam
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·G R ParkP Ferenci
Apr 3, 2009·Journal of Neurosurgery. Pediatrics·Pawel G OchalskiP David Adelson
Feb 1, 1991·Annals of Emergency Medicine·S R VoteyJ R Hoffman
Nov 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G R Park
Jan 9, 2004·Clinics in Chest Medicine·Mark D Siegel
Apr 8, 2020·Critical Care Explorations·Kendra J SchomerTimothy E Albertson

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