PMID: 8580738Oct 1, 1995Paper

Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate

Brain Research. Cognitive Brain Research
P K LiD A Johnson

Abstract

The intent of the study was to determine whether altering the metabolism of neurosteroids via blockade of the enzyme, steroid sulfatase, could enhance retention test performance in rats. The steroid sulfatase inhibitor estrone-3-O-sulfamate (EMATE) was administered alone and in combination with the neurosteroid dehydroepiandrosterone sulfate (DHEAS) to rats which were then tested for the reversal of scopolamine induced amnesia. EMATE enhanced the reversal of amnesia by DHEAS as measured by a passive avoidance test. When administered without DHEAS, as a single acute dose, EMATE had no effect. When administered without DHEAS over 10 consecutive days, however, EMATE significantly improved retention. These results suggest that steroid sulfatase inhibition can potentiate the memory enhancing properties of DHEAS. The study also suggests that increasing the levels of endogenous sulfated neurosteroids via the inhibition of steroid sulfatase activity may enhance learning and/or memory function.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J F FloodE Roberts
May 10, 1988·Brain Research·J F Flood, E Roberts
Nov 1, 1988·Behavioral and Neural Biology·D K Rush
May 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S H Mellon
Jan 1, 1994·Life Sciences·S Rivas-Arancibia, F Vazquez-Pereyra
Jan 21, 1994·Journal of Medicinal Chemistry·N M HowarthB V Potter
Jan 1, 1994·Trends in Endocrinology and Metabolism : TEM·P Robel, E E Baulieu

❮ Previous
Next ❯

Citations

Aug 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·M I Hidalgo AragonesM J Reed
Dec 4, 2003·Bioorganic & Medicinal Chemistry Letters·Erwin P SchreinerAndreas Billich
Feb 14, 2002·Mechanisms of Ageing and Development·Seyed Khosrow TayebatiDamiano Zaccheo
May 6, 1999·Brain Research Bulletin·S Aldred, R H Waring
Apr 3, 2001·The Journal of Steroid Biochemistry and Molecular Biology·B MaliniM J Reed
Apr 25, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Delphine S FischerBarry V L Potter
Jan 12, 1999·The Journal of Steroid Biochemistry and Molecular Biology·J NedvídkováL Stárka
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·A PurohitM J Reed
Oct 23, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Robert N Hughes, Maria T Otto
Jul 27, 2007·Pharmacology & Therapeutics·Synthia H Mellon
Jun 10, 2015·Journal of Receptor and Signal Transduction Research·Colin G Rousseaux, Stephanie F Greene
Jan 18, 2011·Molecular and Cellular Endocrinology·L W Lawrence WooBarry V L Potter
Apr 28, 2004·Bioorganic & Medicinal Chemistry·Hatem A M HejazBarry V L Potter
Dec 11, 2007·Neurochemistry International·Michael SchumacherEtienne-Emile Baulieu
Nov 5, 1997·Endocrinology·N A CompagnoneS H Mellon
Nov 25, 2004·Endocrine Reviews·M J ReedB V L Potter
May 21, 2015·Journal of Medicinal Chemistry·Mark P Thomas, Barry V L Potter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.