Jan 3, 2012

Reversal of scopolamine-induced disruption of prepulse inhibition by clozapine in mice

Pharmacology, Biochemistry, and Behavior
Philipp Singer, Benjamin K Yee

Abstract

Prepulse inhibition (PPI) of the acoustic startle reflex refers to the reduction of the startle response to an intense acoustic pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus and provides a cross-species measure of sensory-motor gating. PPI is typically impaired in schizophrenia patients, and a similar impairment can be induced in rats by systemic scopolamine, a muscarinic cholinergic receptor antagonist that can evoke a range of cognitive and psychotic symptoms in healthy humans that are commonly referred to as the "anti-muscarinic syndrome" resembling some clinical features of schizophrenia. Scopolamine-induced PPI disruption has therefore been proposed as an anti-muscarinic animal model of schizophrenia, but parallel investigations in the mouse remain scant and the outcomes are mixed and often confounded by an elevation of startle reactivity. Here, we distinguished the PPI-disruptive and the confounding startle-enhancing effects of scopolamine (1 and 10mg/kg, i.p.) in C57BL/6 wild-type mice by showing that the latter partly stemmed from a shift in spontaneous baseline reactivity. With appropriate correction for between-group differences in startle reactivity, we went on to confirm that t...Continue Reading

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Antipsychotic Effect
Atypical Antipsychotic [EPC]
Neurobehavioral Manifestations
Assay OF Haloperidol
Schizophrenia
C57BL/6 Mouse
Clozapine
Antagonist Muscle Action
Acute Cholinergic Dysautonomia

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