PMID: 3766092Jul 1, 1986Paper

Reversal of sedation and respiratory depression after anaesthesia by the combined use of physostigmine and naloxone in neurosurgical patients

Acta Anaesthesiologica Scandinavica
L Wiklund

Abstract

A clinical trial of the combination of naloxone in a low dose (1-1.5 micrograms X kg-1 body weight) with physostigmine (0.5-1.0 mg i.v.) was made to elucidate whether this combination could reverse postanaesthetic overdosing in neurosurgical patients without increasing postoperative pain. The investigation was made following previous findings that physostigmine has analgesic properties in addition to its systemic antisedative and anticholinergic effects as well as a stimulatory effect on morphine-depressed ventilation. Altogether 198 neurosurgical patients were investigated. The results showed that postanaesthetic over-sedation can be safely treated by a combination of naloxone and physostigmine in the dosages named above, resulting in the rapid reversal of sedation, where opiates, neuroleptics and benzodiazepines have been used. In contrast, this combination has very little effect on sedation following the administration of agents such as halothane and isoflurane. In the great majority of patients (95%), the treatment resulted in excellent analgesia during the first postoperative hour. The incidence of nausea and vomiting was increased somewhat by this treatment, but these side-effects could be minimized by decreasing the rate...Continue Reading

References

Jul 1, 1979·Canadian Anaesthetists' Society Journal·J C DrummondP S Young
Nov 1, 1977·Canadian Anaesthetists' Society Journal·G E HillC R Sentker
Jan 1, 1978·Acta Anaesthesiologica Scandinavica·S M Aquilonius, U Hedstrand
Jan 1, 1976·Acta Anaesthesiologica Scandinavica·S Arnér, E Gordon
Nov 1, 1976·Canadian Anaesthetists' Society Journal·D E Thompson
Feb 1, 1976·European Journal of Pharmacology·F C TulunayA E Takemori
Dec 1, 1971·British Journal of Pharmacology·B J Pleuvry, M A Tobias
Mar 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·H E Dayton, R L Garrett
Nov 25, 1968·JAMA : the Journal of the American Medical Association·R C Duvoisin, R Katz
Feb 1, 1982·Acta Anaesthesiologica Scandinavica·E Nilsson, J J Himberg
Oct 1, 1981·Acta Anaesthesiologica Scandinavica·M Salmenperä, E Nilsson

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Citations

Nov 1, 1987·Peptides·G A OlsonA J Kastin
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·J KeseciogluW Erdmann
Feb 22, 2008·Best Practice & Research. Clinical Anaesthesiology·Edward C NemergutSabine Himmelseher
Nov 1, 1989·Acta Anaesthesiologica Scandinavica·P HartvigL Wiklund
Jan 1, 1988·Acta Anaesthesiologica Scandinavica. Supplementum·E GellerV Rudick
Feb 3, 1998·Anesthesiology·E P HornJ Schulte am Esch

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