Reversal of sensory deficit through sacral neuromodulation in an animal model of fecal incontinence

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
J EversJ F X Jones

Abstract

Sacral neuromodulation (SNM) is a treatment option for intractable fecal incontinence. The mechanism of action is unclear, however, increasing evidence for afferent somatosensory effects exists. This study's aim was to elucidate effects of acute SNM on the cerebral cortex in a rodent model of pudendal nerve injury. The effects of 14 Hz and 2 Hz SNM on sensory cortical activation were studied. In 32 anesthetized rats, anal canal evoked potentials (EPs) were recorded over the primary somatosensory cortex. Pudendal nerve injury was produced by 1-hour inflation of two intra-pelvic balloons. Four groups were studied: balloon injury, balloon injury plus either 14 Hz or 2 Hz SNM, sham operation. Immunohistochemistry for the neural plasticity marker polysialylated neural cell adhesion molecule (PSA-NCAM) positive cells (numerical density and location) in the somatosensory cortex was performed. Anal EP amplitudes diminished during balloon inflation; 14 Hz SNM restored diminished anal EPs to initial levels and 2 Hz SNM to above initial levels. Evoked potential latencies were prolonged during balloon inflation. The numerical density of PSA-NCAM positive cells increased in the SNM groups, but not in sham or balloon injury without SNM. Stim...Continue Reading

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Citations

Oct 23, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Ludovic LangloisGuillaume Gourcerol
Jan 23, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Keira TurnerJames F X Jones
Aug 28, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Keira TurnerJames F X Jones
Jul 21, 2017·Journal of Clinical Gastroenterology·Paul T J JanssenStephanie O Breukink
Aug 19, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Perla DouvenGommert A van Koeveringe
May 10, 2017·Diseases of the Colon and Rectum·Judith EversP Ronan O'Connell
Apr 9, 2018·Irish Journal of Medical Science·James F X Jones
Mar 19, 2019·Healthcare Technology Letters·Nada YousifYasuko Maeda
Oct 4, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Charles H KnowlesUNKNOWN European SNM Expert Group
Jun 23, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Satish S C RaoShaheen Hamdy

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