Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex.

Neuroscience Bulletin
Bin YuZi-Long Qiu

Abstract

Methyl-CpG binding protein 2 (MeCP2) is a basic nuclear protein involved in the regulation of gene expression and microRNA processing. Duplication of MECP2-containing genomic segments causes MECP2 duplication syndrome, a severe neurodevelopmental disorder characterized by intellectual disability, motor dysfunction, heightened anxiety, epilepsy, autistic phenotypes, and early death. Reversal of the abnormal phenotypes in adult mice with MECP2 duplication (MECP2-TG) by normalizing the MeCP2 levels across the whole brain has been demonstrated. However, whether different brain areas or neural circuits contribute to different aspects of the behavioral deficits is still unknown. Here, we found that MECP2-TG mice showed a significant social recognition deficit, and were prone to display aversive-like behaviors, including heightened anxiety-like behaviors and a fear generalization phenotype. In addition, reduced locomotor activity was observed in MECP2-TG mice. However, appetitive behaviors and learning and memory were comparable in MECP2-TG and wild-type mice. Functional magnetic resonance imaging illustrated that the differences between MECP2-TG and wild-type mice were mainly concentrated in brain areas regulating emotion and social ...Continue Reading

References

Sep 8, 2004·Human Molecular Genetics·Ann L CollinsHuda Y Zoghbi
Oct 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Juan I YoungHuda Y Zoghbi
Dec 19, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Daniela del GaudioBenjamin B Roa
Nov 9, 2007·Neuron·Maria Chahrour, Huda Y Zoghbi
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megumi AdachiLisa M Monteggia
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rodney C SamacoJeffrey L Neul
Apr 29, 2010·American Journal of Medical Genetics. Part a·Melissa B RamockiSarika U Peters
Dec 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minghui JiangStelios M Smirnakis
Aug 1, 2014·Frontiers in Behavioral Neuroscience·Stephen A AllsopKay M Tye
Aug 2, 2014·Neuroscience Bulletin·Tian-Lin Cheng, Zilong Qiu
Oct 20, 2014·Nature Biotechnology·Lukasz SwiechFeng Zhang
May 21, 2015·Nature Reviews. Neuroscience·Philip TovoteAndreas Lüthi
Sep 9, 2015·Molecular Psychiatry·S NageshappaA R Muotri
Mar 2, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan LiVadim Y Bolshakov
Feb 26, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yalun TanEric G Krause

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Citations

Sep 10, 2020·Journal of Neurochemistry·Luis A- Trujillo VillarrealAlberto Camacho-Morales
Nov 17, 2020·Frontiers in Neuroscience·Fábio Duarte, Nicole Déglon
May 1, 2021·International Journal of Molecular Sciences·Ana Rita GomesMaria Margarida Diogo
May 5, 2021·Genes, Brain, and Behavior·Bridget E CollinsJeffrey L Neul
Feb 28, 2021·Journal of Neurochemistry·Santosh R D'Mello
Aug 29, 2021·Pharmaceuticals·Marcin JanowskiAleksandra Pękowska
Oct 15, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sharon M Kolk, Pasko Rakic
Nov 14, 2021·Neuroscience Bulletin·Juanxian ChengHaitao Wu

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Methods Mentioned

BETA
PCR
transgenic

Software Mentioned

GraphPad Prism
ImageJ
REST Analysis Toolkit
Advanced Neuroimaging Tools
FreezeFrame
SPSS
Ethovision XT
Anilab
Actimetrics
SPM8

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