PMID: 6443632Jan 1, 1984

Reversal of the promotional effect of high-fat diet on mammary tumorigenesis by subsequent lowering of dietary fat

Nutrition and Cancer
R Kalamegham, K K Carroll

Abstract

Female Sprague-Dawley rats were given 7,12-dimethylbenz(a)anthracene at 50 days of age to induce mammary tumors, and beginning one week later were fed a high-fat, semipurified diet containing 20% sunflowerseed oil to promote tumor development. After another 7 weeks, when one third of the rats had palpable mammary tumors, the rats were randomly assigned to five groups of 31 animals each, with the same number of tumor-bearers in each group. One group was continued on the high-fat diet, another was given a fat-free diet, and the three remaining groups were fed diets containing 10% lard, butter, or coconut oil, respectively. During the next 29 weeks, rats fed the diets containing 0% or 10% fat developed significantly fewer tumors than those continued on the 20% fat diet. The diets containing 10% fat suppressed tumorigenesis at least as effectively as the fat-free diet. Rats fed the 10% butter and 10% lard diets had growth rates comparable to those fed the 20% sunflowerseed-oil diet throughout, and evidence of essential fatty acid deficiency was seen only in rats on the fat-free diet. These results provide additional evidence that high-fat diets promote development of mammary cancer and suggest that reducing the level of dietary fat...Continue Reading

References

Mar 1, 1977·Journal of the National Cancer Institute·G J Hopkins, C E West
Feb 1, 1976·Journal of the National Cancer Institute·G A Rao, S Abraham
Dec 1, 1980·Psychiatry Research·C Kirkegaard, B J Carroll
Jan 1, 1983·Nutrition and Cancer·R S Sandler
Jan 1, 1982·Nutrition and Cancer·M B Davidson, K K Carroll
Jan 1, 1983·International Journal of Health Services : Planning, Administration, Evaluation·N Makhoul
May 15, 1981·Cancer·I Berenblum

Citations

Jan 1, 1984·Nutrition and Cancer·K K Carroll, L M Braden
May 21, 2015·Experimental Biology and Medicine·Iwona MalickaMarek Wozniewski
Jul 1, 1987·Preventive Medicine·L A Cohen
Jul 1, 1987·Preventive Medicine·K K Carroll
Oct 15, 1986·Cancer·K K CarrollR Kalamegham
May 1, 1991·Breast Cancer Research and Treatment·L Le Marchand
Jul 31, 1997·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M NoguchiK Miwa

Related Concepts

Ghee
Saturated Fat
Mammary Neoplasms, Experimental
August Rats
9,10-Dimethyl-1,2-benzanthracene

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