Reversal of trimethoprim-induced antikaliuresis

Kidney International
I W ReiserJ G Porush

Abstract

High-dose trimethoprim-sulfamethoxazole (TMP-SMX) causes hyperkalemia, thought to result from TMP-induced blockade of amiloride-sensitive Na(+)-channels in the distal nephron. The present study was performed in anesthetized dogs to determine if increasing distal sodium delivery affects this antikaliuretic effect. In Group 1, intrarenal infusion of vehicle did not alter renal function. In Group 2, i.v. infusion of amiloride led to diuresis, natriuresis and antikaliuresis associated with a reduction of the transtubular potassium gradient (TTKG) in both kidneys. Intrarenal infusion of TMP (0.2 mg/kg/min) into the left kidney did not further alter these parameters. In groups 3 and 4, intrarenal infusion of TMP caused an ipsilateral diuresis, natriuresis, antikaliuresis and a reduction in (TTKG) without affecting the contralateral kidney. The TMP infusion was followed by furosemide (20 mg i.v.) in group 3 and acute saline loading in group 4. Despite continuous TMP infusion, both furosemide and saline loading reversed the antikaliuretic effect of TMP in the ipsilateral kidney and was associated with a similar kaliuresis, diuresis, natriuresis and decrease in urine osmolality in both kidneys. The TTKG following furosemide or saline lo...Continue Reading

References

May 1, 1976·The American Journal of Physiology·S F WenJ H Dirks
Aug 1, 1974·The American Journal of Physiology·L C StonerJ Orloff
Jul 1, 1970·The American Journal of Physiology·J H Dirks, J F Seely
Nov 1, 1967·The American Journal of Physiology·C M BennettR W Berliner
Oct 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K S KamelM L Halperin
Aug 15, 1993·Annals of Internal Medicine·S GreenbergJ G Porush
Aug 15, 1993·Annals of Internal Medicine·H VelázquezD H Ellison
Jul 1, 1993·The Journal of General Physiology·J PáchaL G Palmer
Feb 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S VasuvattakulM L Halperin
Mar 11, 1993·The New England Journal of Medicine·M J ChoiT R Kleyman
Jan 1, 1996·Kidney International·M SchreiberT R Kleyman

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Citations

Mar 27, 2009·Nature Reviews. Nephrology·R ZietseE J Hoorn
Apr 17, 2008·Journal of the American Veterinary Medical Association·Davis M SeeligPaul R Avery
Mar 1, 2006·Expert Opinion on Drug Safety·Christina M Wyatt, Paul E Klotman
Dec 17, 2009·Advances in Chronic Kidney Disease·Jennifer Jao, Christina M Wyatt
Sep 8, 2005·Journal of Intensive Care Medicine·Kimberley J Evans, Arthur Greenberg
Mar 30, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M A Perazella
Feb 22, 2008·American Journal of Physiology. Renal Physiology·Roland Schmitt, Lloyd G Cantley
Jun 19, 2012·Sociology of Education·John R LoganSinem Adar

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