PMID: 7032642Dec 1, 1981Paper

Reversal of vasectomy: the effects of sperm antibodies on subsequent fertility

British Journal of Urology
M G RoyleW F Hendry

Abstract

Antisperm antibodies were measured in serum and seminal plasma in 130 males before and after vasectomy reversal and the occurrence of pregnancy was analysed in the partners of 77 who were followed for more than one year. Sperm-agglutinating antibodies were found in the serum of 79% of patients; seminal plasma antibodies were present in only 9.5% before reversal and this rose to 26% afterwards. Pregnancies occurred in the partners of 53% of those men who were trying to produce children. A pregnancy was significantly less likely when the pre-operative serum antisperm antibody titre was 512 or more, but no decrease in fertility was seen with titres below this. Several pregnancies were produced by patients with seminal plasma antibodies, but numbers and follow-up are too small to permit detailed analysis. A randomised controlled trial of per-operative steroids showed that they produced no benefit. The antisperm antibodies associated with vasectomy reversal appear to differ fundamentally from those occurring in naturally subfertile males.

References

Aug 1, 1977·The Journal of Urology·K F Hagan, D S Coffey
Jun 7, 1979·The New England Journal of Medicine·G Largey
May 1, 1978·Urology·S Marshall
Feb 1, 1977·The Journal of Urology·M J Sullivan, G E Howe
Oct 1, 1973·Fertility and Sterility·R Ansbacher

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Citations

Mar 1, 1990·Journal of Reproductive Immunology·H H HandleyJ C Herr
Sep 1, 1991·Journal of Reproductive Immunology·H H HandleyC J Flickinger
Feb 1, 1995·Journal of Reproductive Immunology·C J FlickingerJ C Herr
Oct 1, 1994·Journal of Reproductive Immunology·C J FlickingerJ C Herr
Sep 2, 1988·Journal of Chromatography·K Peck, M D Morris
Oct 8, 1983·Lancet·R J HancockA May
Sep 1, 1992·American Journal of Reproductive Immunology : AJRI·H Meinertz
Jan 1, 1983·American Journal of Reproductive Immunology : AJRI·J M ParslowW F Hendry
Oct 1, 1984·British Journal of Urology·M UpadhyayaS M Walker
Dec 1, 1982·British Journal of Urology·W F HendryD M Wallace
Jan 1, 1989·British Journal of Obstetrics and Gynaecology·P K IqbalJ Cuthbert
Jul 1, 1986·Journal of Biosocial Science·L Clarke, S Gregson

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