REVERSE 5-year follow up: CRT impact persists

Global Cardiology Science & Practice
Mohamed ElMaghawry, Mahmoud Farouk

Abstract

The role of cardiac resynchronization therapy (CRT) in patients presenting with mild manifestations of heart failure (HF), depressed left ventricular ejection fraction (LV EF), and wide QRS complex, has been addressed in four previous trials: MIRACLE ICD II,(1) MADIT-CRT,(2) RAFT,(3) and REVERSE.(4) The consistent observed benefits in reverse cardiac remodelling and reduction of heart failure adverse events have resulted in guideline recommendations for CRT in NYHA Class II patients. The guidelines also recommend further studies to determine whether survival is increased by CRT in patients with mild symptoms. The 5-year analysis of the REsynchronization reVErses Remodeling Systolic left vEntricular (REVERSE) trial, which was designed prospectively for 5-year follow-up to specifically assess the long term benefits of CRT, were recently published in the European Heart Journal.(5).

References

May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Nov 29, 2008·Journal of the American College of Cardiology·Cecilia LindeUNKNOWN REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
Nov 16, 2010·The New England Journal of Medicine·Anthony S L TangUNKNOWN Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators
May 4, 2013·European Heart Journal·Cecilia LindeUNKNOWN REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction Study Group

❮ Previous
Next ❯

Software Mentioned

COMPANION
MADIT
REVERSE
HF

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.