Reverse effects of conditioning produced by two different unconditioned stimuli on thalamocortical transmission

Journal of Neurophysiology
E M Meftah, L Rispal-Padel

Abstract

Actions of cerebellothalamocortical (CTC) networks on the musculature can be modified by associative conditioning in adult animals. During conditioning, electrical stimulation of a CTC network involved in forearm flexion movements results in either flexion or extension responses, depending on the somatosensory information given by the unconditioned stimulus (UCS). In the present work we attempt to determine what kind of neurobiological changes induced in the CTC pathways as a consequence of distinct somesthetic messages could lead to different conditioned motor responses. Two conditioning procedures in which distinct UCSs were successively applied to awake cats in chronic preparation. The conditioned stimulus (CS) was an electrical subthreshold stimulation of an interpositus nucleus (IN) site at the origin of CTC circuits controlling forelimb flexion movements. It was first paired with a UCS applied to the skin above the wrist, also producing a forearm flexion reflex, and second with a UCS applied more proximally on the forearm, producing a backward withdrawal reflex of the forelimb. The two procedures, termed "concordant" and "discordant," respectively, were carried out in a different order on the same cats, separated by 2 mo ...Continue Reading

References

Oct 13, 1978·Experimental Brain Research·A Baranyi, O Fehér
Nov 21, 1977·Journal of Theoretical Biology·T J Sejnowski
Oct 20, 1977·Journal of Mathematical Biology·T J Sejnowski
Apr 9, 1976·Brain Research·A Nieoullon, L Rispal-Padel
Sep 22, 1989·Science·A IrikiH Asanuma
Dec 4, 1989·Brain Research·T SakamotoH Asanuma
Apr 1, 1988·Behavioural Brain Research·Y Padel, J L Relova
Feb 14, 1986·Neuroscience Letters·Y PadelE Sybirska
Aug 1, 1972·Experimental Neurology·K Sasaki, S Prelević
Oct 1, 1974·Physiological Reviews·G I Allen, N Tsukahara
Nov 1, 1973·Journal of Neurophysiology·C D Woody, P Black-Cleworth
Jan 22, 1974·Experimental Brain Research·L Rispal-Padel, J Latreille
Jul 1, 1982·The Journal of Physiology·B E Alger, R A Nicoll
Mar 10, 1981·Neuroscience Letters·L Rispal-PadelC Pons
Jul 1, 1995·Cerebral Cortex·V A Aroniadou, A Keller
Sep 1, 1993·Cerebral Cortex·Y ShinodaT Wannier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.