PMID: 9165345May 1, 1997Paper

Reverse middle-ear transfer function in the guinea pig measured with cubic difference tones

Hearing Research
P MagnanR Probst

Abstract

Otoacoustic emissions are increasingly useful for determining cochlear function noninvasively. It is widely agreed that these acoustic signals reflect micromechanical processes in the cochlea. However, their quantitative interpretation requires knowledge of the ways in which vibrations travelling back to the ear canal from the cochlea are shaped by the middle ear. An intracochlear source is needed to derive the reverse middle-ear transfer function (rMETF) by comparing pressure in the external ear canal to the corresponding pressure in scala vestibuli. In the present study, the rMETF was obtained in vivo in the guinea pig using as intracochlear sound source the cubic difference tones (CDTs) generated by a pair of external pure tones. With a closed ear canal and open bulla, the rMETF was found to be flat (-35 dB) over a broad frequency range (1.5-8 kHz). The differences between forward and reverse METF could be explained by different loads acting on the middle ear network, which depends on the direction of signal transmission. With knowledge of the rMETF, it becomes possible to quantify CDTs within the cochlea by measuring them noninvasively in the ear canal.

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Citations

Apr 3, 2012·Journal of the Association for Research in Otolaryngology : JARO·Wei DongElizabeth S Olson
Nov 28, 2012·Hearing Research·Wei DongElizabeth S Olson
Jun 17, 2005·The Journal of the Acoustical Society of America·Wei Dong, Elizabeth S Olson
Jul 22, 1998·The Journal of the Acoustical Society of America·R H WithnellG K Yates
Jan 28, 1999·The Journal of the Acoustical Society of America·M Faulstich, M Kössl
Mar 25, 2010·The Journal of the Acoustical Society of America·Michaël C C SlamaJohn J Rosowski
Mar 14, 2007·Hearing Research·Wenxuan HeTianying Ren
Dec 3, 2016·Journal of the Association for Research in Otolaryngology : JARO·Wei Dong
Aug 1, 1997·The Journal of the Acoustical Society of America·G A Manley, L Gallo
Nov 10, 2004·The Journal of the Acoustical Society of America·Susan E Voss, Christopher A Shera
Dec 14, 2016·IEEE Transactions on Bio-medical Engineering·Nan XiaClaus-Peter Richter
Oct 27, 2006·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Elizabeth S Olson, Wei Dong
Jun 30, 2007·Journal of Basic and Clinical Physiology and Pharmacology·Jean-Yves SichelHaim Sohmer
Oct 19, 2013·Physiological Reviews·Paul AvanChristine Petit
Feb 17, 2006·Journal of Neurophysiology·Wei Dong, Elizabeth S Olson
Dec 18, 2012·Biomedical Optics Express·Michael SchultzAndrej Kral
Jun 28, 2001·Physiological Reviews·L Robles, M A Ruggero
Feb 4, 2019·The Journal of the Acoustical Society of America·Jeffrey Tao ChengJohn Rosowski
May 27, 2003·The Journal of the Acoustical Society of America·Sunil Puria
Nov 1, 2016·Journal of the Association for Research in Otolaryngology : JARO·Maryam Naghibolhosseini, Glenis R Long
Dec 29, 2020·Progress in Biophysics and Molecular Biology·Yingyue XuClaus-Peter Richter
Feb 17, 2021·Journal of the Association for Research in Otolaryngology : JARO·Xiaohui LinWei Dong

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