Reverse remodeling and improved function by antihypertensive treatment in hypertensive patients with coronary artery disease

Journal of Hypertension
Yoshiki YuiJapan Multicenter Investigation for Cardiovascular Diseases B (JMIC-B) Study Group

Abstract

Although antihypertensive therapy reduces cardiovascular events, it is unclear whether there are differences in cardiac remodeling and function between treatments with nifedipine retard and angiotensin-converting enzyme inhibitors (ACE-Is). It is also not clear how antihypertensive therapy influences cardiac remodeling and function. Hypertensive patients with coronary artery disease were randomly assigned to the nifedipine retard (n = 108) or ACE inhibitors groups (n = 102) and treated for 3 years. The primary endpoints were changes in end-diastolic volume index (EDVI) and end-systolic volume index (ESVI) as indices of cardiac remodeling, whereas the secondary endpoints were changes in ejection fraction (EF), stroke volume index (SVI), cardiac index (CI) and regional wall motion as indices of cardiac function. Left ventriculography was performed at baseline and after 3 years of treatment. Fifty-eight and 61 patients, respectively, were subjected to the final analysis. Comparable changes in remodeling and function were obtained in the nifedipine retard group and the ACE-Is group. Both groups showed a significant reduction of EDVI and ESVI, and a significant increase in EF, SVI, and CI, whereas the decreased regional wall motion ...Continue Reading

References

Oct 30, 2003·Journal of Cardiac Failure·Marvin A KonstamJay N Cohn
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Jan 7, 2004·Circulation·Robert N DoughtyUNKNOWN CAPRICORN Echo Substudy Investigators
Apr 15, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshiki YuiUNKNOWN Japan Multicenter Investigation for Cardiovascular Diseases-B Study Group
Apr 27, 2005·Hypertension·Eiji ShinodaUNKNOWN Japan Multicenter Investigation for Cardiovascular Diseases-B Study Group
Sep 22, 2007·Journal of Hypertension·Yoshiki YuiUNKNOWN Japan Multicenter Investigation for Cardiovascular Diseases B (JMIC-B) Study Group

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Citations

Mar 6, 2013·The Journal of Clinical Hypertension·Yoshiki YuiUNKNOWN Japan Multicenter Investigation for Cardiovascular DiseaseB (JMIC-B) Study Group
Jun 22, 2018·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Vijai Datta UpadhyayaEti Sthapak

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