Reverse signaling via a glycosyl-phosphatidylinositol-linked ephrin prevents midline crossing by migratory neurons during embryonic development in Manduca.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Thomas M CoateP F Copenhaver

Abstract

We have investigated whether reverse signaling via a glycosyl-phosphatidylinositol (GPI)-linked ephrin controls the behavior of migratory neurons in vivo. During the formation of the enteric nervous system (ENS) in the moth Manduca, approximately 300 neurons [enteric plexus (EP) cells] migrate onto the midgut via bilaterally paired muscle bands but avoid adjacent midline regions. As they migrate, the EP cells express a single ephrin ligand (MsEphrin; a GPI-linked ligand), whereas the midline cells express the corresponding Eph receptor (MsEph). Blocking endogenous MsEphrin-MsEph receptor interactions in cultured embryos resulted in aberrant midline crossing by the neurons and their processes. In contrast, activating endogenous MsEphrin on the EP cells with dimeric MsEph-Fc constructs inhibited their migration and outgrowth, supporting a role for MsEphrin-dependent reverse signaling in this system. In short-term cultures, blocking endogenous MsEph receptors allowed filopodia from the growth cones of the neurons to invade the midline, whereas activating neuronal MsEphrin led to filopodial retraction. MsEphrin-dependent signaling may therefore guide the migratory enteric neurons by restricting the orientation of their leading proc...Continue Reading

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Citations

Mar 30, 2012·Neuro-Signals·Jennifer RodgerPaolo Migani
Jun 14, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenna M RamakerPhilip F Copenhaver
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas M CoatePhilip F Copenhaver
Dec 18, 2012·Biology of Reproduction·Adrian V Buensuceso, Bonnie J Deroo
Dec 10, 2016·Frontiers in Molecular Neuroscience·Jenna M RamakerPhilip F Copenhaver

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