PMID: 2484912Nov 1, 1988Paper

Reverse transcriptase activity in 5-azacytidine-treated lymphocyte cultures of patients with schizophrenia

Schizophrenia Research
A FeenstraR J Wyatt

Abstract

We investigated the involvement of human lymphotropic retroviruses in the etiology of schizophrenia. Short-term cultures of peripheral lymphocytes of 11 chronic schizophrenic patients and six controls were established and treated with 2.5 and 5 microM 5-azacytidine. No reverse transcriptase activity could be detected in any of the 5-azacytidine-treated cultures indicating that 5-azacytidine did not activate a putative retrovirus in lymphocytes of patients with schizophrenia. Therefore, our findings do not support a role of lymphotropic retroviruses as an etiology in schizophrenia.

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Citations

Jan 1, 1993·European Archives of Psychiatry and Clinical Neuroscience·M KokaiT Tachibana
Oct 1, 1991·Schizophrenia Research·M A CoggianoH Kulaga
Feb 16, 1996·American Journal of Medical Genetics·R L O'Reilly, S M Singh
Jun 1, 1994·The Australian and New Zealand Journal of Psychiatry·R L O'Reilly
Mar 27, 2003·Neuroreport·Håkan Karlsson
Jan 1, 1995·Clinical Microbiology Reviews·R H Yolken, E F Torrey

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