Reverse transcriptase in bacteria.

Molecular Microbiology
D Lim, W K Maas

Abstract

Reverse transcriptase, discovered in 1970 in retroviruses, has until recently been found only in eukaryotic organisms. Recently it was shown to occur in two groups of bacteria: myxobacteria and Escherichia coli. The gene for reverse transcriptase is part of a chromosomal genetic element that codes for the production of a branched DNA-RNA compound. In this compound a single-stranded DNA is connected to RNA at a specific G residue by a 2'-5' phosphodiester linkage. The precursor for the DNA-RNA compound is a folded messenger RNA, in which the specific G residue is the initiation point for reverse transcription. In the final DNA-RNA compound, the portion of the RNA transcribed by reverse transcriptase is eliminated by RNase H. The DNA-RNA compound is present in several hundred copies per cell. Its biological function is unknown at present.

References

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Citations

Aug 1, 1993·Plant Molecular Biology·I Manninen, A H Schulman
Jan 1, 1990·Pharmacology & Therapeutics·U Wintersberger
Jun 3, 2009·Antimicrobial Agents and Chemotherapy·J Brooks JacksonKaren C Carroll
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Apr 1, 2016·The Pediatric Infectious Disease Journal·Mwila KabweMatthew Bates
Apr 1, 1992·Journal of Bacteriology·M Inouye, S Inouye
Feb 2, 1990·Science·D Shippen-Lentz, E H Blackburn

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