PMID: 7326234Dec 22, 1981Paper

Reversed unfolding-refolding process of cobra neurotoxin

A GałatE R Blout


Circular dichroism and nuclear magnetic resonance spectroscopies have been used to study the unfolding process of cobrotoxin upon addition of fluoro alcohols/or sodium dodecyl sulfate to its aqueous solution. In each final unfolded state, the protein had its disulfide bonds intact. The unfolding process has been found to be reversible in the case of fluoro alcohol/water mixtures, while no such reversibility was found in the case of sodium dodecyl sulfate. However, when hexafluoro-2-propanol is added to the sodium dodecyl sulfate unfolded protein, refolding is induced. The mechanism of unfolding is discussed in terms of the different interactions which govern the protein conformation in solution.


Dec 20, 1978·Biochimica Et Biophysica Acta·T H HseuC C Yang
Dec 17, 1979·European Journal of Biochemistry·T EndoT Miyazawa
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D Tsernoglou, G A Petsko
Jan 1, 1978·Progress in Biophysics and Molecular Biology·T E Creighton
Feb 6, 1979·Biochemistry·C H FungR K Gupta
Mar 28, 1978·Biochimica Et Biophysica Acta·L Visser, A I Louw
May 3, 1977·Biochemistry·Y H ChenJ T Yang
Jun 20, 1977·Biochemical and Biophysical Research Communications·J LauterweinM Lazdunski
Jan 1, 1976·Toxicon : Official Journal of the International Society on Toxinology·E Karlsson, J Sundelin
Nov 26, 1976·Biochimica Et Biophysica Acta·A MenezP Fromageot
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B W LowJ S Richardson
Jan 1, 1972·Annual Review of Pharmacology·C Y Lee
Dec 23, 1974·Biochemical and Biophysical Research Communications·D W UrryM Jacobs
Jan 1, 1974·Toxicon : Official Journal of the International Society on Toxinology·C C Yang
Sep 29, 1970·Biochimica Et Biophysica Acta·A SetoN Tamiya
Jan 1, 1972·Biopolymers·J R Parrish, E R Blout
Jul 27, 1970·Biochimica Et Biophysica Acta·B Jirgensons, S Capetillo
Oct 21, 1968·Biochimica Et Biophysica Acta·C C YangK Hamaguchi


Jan 1, 1982·The International Journal of Biochemistry·A Galat
Jan 1, 1982·The International Journal of Biochemistry·A Gałat
Jan 1, 1983·The International Journal of Biochemistry·A Gałat
Apr 28, 1997·Biochemical and Biophysical Research Communications·J R Cort, N H Andersen
Jan 1, 1983·CRC Critical Reviews in Biochemistry·M J Dufton, R C Hider
Jul 1, 1987·International Journal of Peptide and Protein Research·J M SabatierJ Van Rietschoten
Jul 4, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jean-Pierre DjukicSnežana D Zarić

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.