Reversibility and relaxation behavior of polyelectrolyte complex micelle formation

The Journal of Physical Chemistry. B
Saskia LindhoudMartien A Cohen Stuart

Abstract

In this study, the formation and disintegration of polyelectrolyte complex micelles is studied by dynamic light scattering titrations with the aim to assess the extent to which these complexes equilibrate. Also, the time evolution of samples at fixed (electroneutral) composition was followed to obtain information about the relaxation time of the complex formation. We find that, in 3.5 mM phosphate buffer with pH 7, polyelectrolyte complex micelles consisting of the positively charged homopolymer PDMAEMA(150), the negatively charged diblock copolymer PAA(42)-PAAm(417) (both having a pH-dependent charge), as well as the positively charged protein lysozyme slowly equilibrate with a relaxation time of about 2 days. The same structures were obtained, independent of the way the polymers and proteins had been mixed. In contrast, polyelectrolyte complex micelles (at the same pH) consisting of (pH-dependent) negatively charged homopolymer PAA(139), the pH-independent positively charged diblock copolymer P2MVP(41)-PEO(205), and the negatively charged protein alpha-lactalbumin did not equilibrate. The way in which solutions containing these macromolecules were mixed yielded different results that did not change over the period of at least...Continue Reading

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Citations

Jan 26, 2011·Physical Chemistry Chemical Physics : PCCP·Fu-Gen WuZhi-Wu Yu
Jan 30, 2010·International Journal of Molecular Sciences·Vincent Ball, Clarisse Maechling
Apr 23, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Joris de GroothKitty Nijmeijer
Oct 20, 2015·Soft Matter·Saskia Lindhoud, Mireille M A E Claessens
Apr 11, 2015·Biomacromolecules·Antsje NollesJan Willem Borst
Nov 15, 2013·Physical Chemistry Chemical Physics : PCCP·Jingyan ZhangShiyong Liu
Jul 13, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Keita NakaiShin-ichi Yusa
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Jul 30, 2017·International Journal of Molecular Sciences·Antsje NollesJan Willem Borst
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Mar 12, 2010·The Journal of Physical Chemistry. B·Yann DesfougèresFrançoise Nau
Apr 15, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Saskia LindhoudMartien A Cohen Stuart
Aug 21, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Saskia LindhoudWillem Norde
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Sep 14, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Antsje NollesJan Willem Borst
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Dec 18, 2020·Macromolecules·Inge BosJoris Sprakel
Aug 24, 2019·ACS Applied Materials & Interfaces·Hursh V SurekaBradley D Olsen

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