Reversibility of acute cyclosporin nephrotoxicity by dopamine. Micropuncture study in the rat

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
M SabbatiniV E Andreucci

Abstract

The ability of dopamine to neutralise the effects acutely induced by cyclosporin (CsA) on glomerular dynamics was evaluated in four groups of female Munich-Wistar rats, prepared for micropuncture: group I (n = 9), normal rats receiving saline as placebo; group II (n = 10), rats treated with CsA (20 mg/kg b.w. in 1 h); group III (n = 8) rats treated with CsA, as in group II, and then with vasodilating doses of dopamine (1.2-2.0 micrograms/100 g b.w./min in continuous intravenous infusion); group IV (n = 7), rats administered Cremophore EL, the vehicle of CsA, in corresponding doses. Single nephron GFR (SNGFR), glomerular plasma flow (GPF), afferent and efferent arteriole resistances (Ra and Re, respectively), SN filtration fraction (SNFF), ultrafiltration coefficient (Kf) were measured. Body weight, blood pressure and haematocrit were similar in the four groups. GFR was significantly reduced in group II (0.83 +/- 0.08 ml/min vs 1.29 +/- 0.01 in group I, 1.46 +/- 0.25 in group III, and 1.40 +/- 0.09 in group IV, P less than 0.05 vs all the groups), while no statistical difference was detected in urinary volume. SNGFR was significantly reduced in group II vs group I (18.7 +/- 1.8 nl/min vs 30.6 +/- 1.3, P less than 0.01).(ABSTRACT...Continue Reading

Citations

Aug 1, 1995·British Journal of Pharmacology·M PestanaP Soares-da-Silva
Sep 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Mason
Jan 8, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rita RezzaniRossella Bianchi
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Houman HomayounAhmad Reza Dehpour
Jul 8, 2000·European Journal of Pharmacology·G RomanoE Bartoli
Oct 1, 1992·Kidney International·M SabbatiniV E Andreucci
Feb 19, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A FassiA Remuzzi

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