Reversibility of azoospermia induced by bacillus Calmette-Guerin

Journal of Andrology
R K Naz, G P Talwar

Abstract

A single intratesticular injection of bacillus Calmette-Guerin induces azoospermia within 3 to 6 weeks in a variety of animals without loss of androgens. After a period of azoospermia, the return of spermatogenesis was observed in dogs and monkeys. Seven dogs that showed aspermatogenesis after a local instillation of bacillus Calmette-Guerin (20-110 units per testis) again demonstrated spermatogenesis after a period of 153 to 325 days of azoospermia. Sperm counts and motility were restored to preimmunization levels within 6 weeks after initiation of spermatogenesis. In one dog, systemic treatment with antimycobacterial drugs helped to clear the bacillus Calmette-Guerin from the testis, thus hastening the reinitiation of spermatogenesis. In two monkeys injected with 110 and 160 units of bacillus Calmette-Guerin, azoospermia lasted up to 150 days. Subsequently, fertility was restored and the treated animals sired healthy offspring. A second injection of bacillus Calmette-Guerin of a lesser dose (5-20 units per testis) in these fertile dogs and monkeys again produced azoospermia. Histologically, the monkeys having a second period of azoospermia demonstrated aspermatogenic orchitis in the testis and leukocyte infiltration in the in...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G P TalwarR P Das
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R K NazA C Menge
Oct 1, 1983·Fertility and Sterility·E F Fuchs, N J Alexander
Feb 1, 1981·International Journal of Andrology·R K Naz, G P Talwar
Sep 1, 1981·Archives of Andrology·G P Talwar, R K Naz
May 1, 1953·The Journal of Experimental Medicine·J FREUNDG E THOMPSON
Apr 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·L MASTROIANNI, W A MANSON

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