PMID: 7086545Jun 1, 1982Paper

Reversibility of development retardation following murine fetal zinc deprivation

The Journal of Nutrition
R S BeachL S Hurley

Abstract

To investigate the effects and reversibility of moderate prenatal zinc deprivation, pregnant mice were fed, beginning on day 7 of gestation, a diet containing either 100 ppm (control) or 5 ppm zinc; pair-fed controls were also studied. Nutritional manipulation was limited to the prenatal period. Zinc-deprived dams had significantly smaller litters than did controls, and postnatal survival was markedly compromised. Progeny of zinc-deprived dams displayed significant growth retardation, as reflected by lower body weight and length than controls, whether ad libitum-fed or pair-fed. Growth of spleen and thymus was affected by zinc deprivation to a significantly greater extent than was growth of heart, kidney or brain. Cross-fostering of control pups to zinc-deprived dams resulted in delayed growth; however, retardation was not as great as that observed in deprived pups allowed to suckle their natural mothers. Cross-fostering of zinc-deprived pups to control dams improved growth of most organs, but did little to improve growth of spleen and, most notably, thymus. Zinc-deprived pups exhibited considerable "catch up" growth following neonatal zinc repletion, and by 6-8 weeks of age, no significant differences between control and depri...Continue Reading

Citations

Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·J Patrick, C Dervish
Nov 17, 2004·Avian Pathology : Journal of the W.V.P.A·Hengmin CuiYang Guang
Feb 15, 2012·Advances in Nutrition·Amanda C Palmer
Sep 1, 1995·Journal of Cellular Physiology·C M Bax, D L Bloxam
Feb 8, 2007·The American Journal of Clinical Nutrition·Hala GhattasDerek C Macallan
Mar 18, 2016·Molecular Neurobiology·Atsushi Takeda, Haruna Tamano
Feb 24, 2006·Nutrition Reviews·Dheeraj Shah, H P S Sachdev
Jul 30, 2011·Journal of the Science of Food and Agriculture·Sanniyasi BakyarajBanabihari Dash
Nov 6, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Juna V KonomiLou Ann S Brown
May 6, 2003·The Journal of Nutrition·Carlos Castillo-Durán, Gerardo Weisstaub

Related Concepts

Animals, Suckling
Fetal Growth Retardation
Litter Size
Tissue Specificity
Pregnancy Complications
Zinc

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