PMID: 7086545Jun 1, 1982Paper

Reversibility of development retardation following murine fetal zinc deprivation

The Journal of Nutrition
R S BeachL S Hurley


To investigate the effects and reversibility of moderate prenatal zinc deprivation, pregnant mice were fed, beginning on day 7 of gestation, a diet containing either 100 ppm (control) or 5 ppm zinc; pair-fed controls were also studied. Nutritional manipulation was limited to the prenatal period. Zinc-deprived dams had significantly smaller litters than did controls, and postnatal survival was markedly compromised. Progeny of zinc-deprived dams displayed significant growth retardation, as reflected by lower body weight and length than controls, whether ad libitum-fed or pair-fed. Growth of spleen and thymus was affected by zinc deprivation to a significantly greater extent than was growth of heart, kidney or brain. Cross-fostering of control pups to zinc-deprived dams resulted in delayed growth; however, retardation was not as great as that observed in deprived pups allowed to suckle their natural mothers. Cross-fostering of zinc-deprived pups to control dams improved growth of most organs, but did little to improve growth of spleen and, most notably, thymus. Zinc-deprived pups exhibited considerable "catch up" growth following neonatal zinc repletion, and by 6-8 weeks of age, no significant differences between control and depri...Continue Reading


Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·J Patrick, C Dervish
Nov 17, 2004·Avian Pathology : Journal of the W.V.P.A·Hengmin CuiYang Guang
Feb 15, 2012·Advances in Nutrition·Amanda C Palmer
Sep 1, 1995·Journal of Cellular Physiology·C M Bax, D L Bloxam
Feb 8, 2007·The American Journal of Clinical Nutrition·Hala GhattasDerek C Macallan
Mar 18, 2016·Molecular Neurobiology·Atsushi Takeda, Haruna Tamano
Feb 24, 2006·Nutrition Reviews·Dheeraj Shah, H P S Sachdev
Jul 30, 2011·Journal of the Science of Food and Agriculture·Sanniyasi BakyarajBanabihari Dash
Nov 6, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Juna V KonomiLou Ann S Brown
May 6, 2003·The Journal of Nutrition·Carlos Castillo-Durán, Gerardo Weisstaub

Related Concepts

Animals, Suckling
Fetal Growth Retardation
Litter Size
Tissue Specificity
Pregnancy Complications

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.