Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet

Laboratory Investigation; a Journal of Technical Methods and Pathology
Yong-ping MuNorifumi Kawada

Abstract

Fatty liver disease has become a health problem related to metabolic syndrome worldwide, although its molecular pathogenesis requires further study. It is also unclear whether advanced fibrosis of steatohepatitis will regress when diet is controlled. The aim of this study was to investigate whether the resolution of fibrosis occurs in steatohepatitis induced by a methionine-choline-deficient diet (MCDD). Manifestation of endoplasmic reticulum (ER) stress in this model was also studied. Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks. Instead of MCDD, a methionine-choline control diet (CD) was given for the last 2 weeks to the experimental group. Fibrosis and inflammation were determined by tissue staining. Protein and gene expressions were determined by immunoblotting and quantitative reverse transcription-PCR (RT-PCR), respectively. Expressions of caspase-7, caspase-12, glucose-regulated protein 78 (GRP78), and protein disulfide isomerase were evaluated to clarify the presence of ER stress. Changing the diet from MCDD to CD triggered the reduction of fat in hepatocytes, a decrease in inflammatory gene expression and oxidative stress, and regression of fibrosis accomp...Continue Reading

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Citations

Aug 2, 2012·Fibrogenesis & Tissue Repair·Masashi IizukaNorifumi Kawada
Aug 25, 2011·Molecular Medicine·Chih-Kang ChiangShing-Hwa Liu
Jan 18, 2014·Cell Death & Disease·K Wang
Dec 4, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hiroyuki MotoyamaNorifumi Kawada
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Mar 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sandra CabreraAnnie Pardo
Mar 19, 2014·Genes & Development·Tongde WuDonna D Zhang

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