Reversibility of neuroimaging markers influenced by lifetime occupational manganese exposure

Toxicological Sciences : an Official Journal of the Society of Toxicology
David A EdmondsonUlrike Dydak

Abstract

Manganese (Mn) is a neurotoxicant that many workers are exposed to daily. There is limited knowledge about how changes in exposure levels impact measures in magnetic resonance imaging (MRI). We hypothesized that changes in Mn exposure would be reflected by changes in the MRI relaxation rate R1 and thalamic γ-aminobutyric acid (GABAThal). As part of a prospective cohort study, 17 welders were recruited and imaged on two separate occasions approximately two years apart. MRI relaxometry was used to assess changes of Mn accumulation in the brain. Additionally, GABA was measured using magnetic resonance spectroscopy (MRS) in the thalamic and striatal regions of the brain. Air Mn exposure ([Mn]Air) and cumulative exposure indexes of Mn (Mn-CEI) for the past three months (Mn-CEI3M), past year (Mn-CEI12M), and lifetime (Mn-CEILife) were calculated using personal air sampling and a comprehensive work history, while toenails were collected for analysis of internal Mn body burden. Finally, welders' motor function was examined using the Unified Parkinson's Disease Rating Scale (UPDRS). Median exposure decreased for all exposure measures between the first and second scan. ΔGABAThal was significantly correlated with ΔMn-CEI3M (ρ = 0.66, adju...Continue Reading

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Citations

Sep 3, 2020·Archives of Toxicology·David A EdmondsonUlrike Dydak
May 1, 2021·International Journal of Molecular Sciences·Alexey A TinkovMichael Aschner
Nov 17, 2021·Experimental Biology and Medicine·Elke AnklamWilliam Slikker

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