Reversibility of the effects of GnRH-vaccination used to suppress reproductive function in mares

Equine Veterinary Journal
M L SchulmanH J Bertschinger

Abstract

Active immunisation against gonadotrophin-releasing hormone (GnRH) provides a reversible method for control of oestrous behaviour and fertility in mares. Previous reports failed to demonstrate the interval to resumption of cyclic ovarian activity after GnRH-vaccination. Administration of the GnRH-vaccine Improvac in a large group of mares of various ages will result in effective, reliably reversible suppression of ovarian activity within a 2 year period. The mares, subdivided into 3 age categories, were vaccinated twice (with a 35 day interval) using 400 µg Improvac and monitored via blood samples until Day 720 after initial vaccination for serum progesterone concentration determination by radioimmune assay and anti-GnRH antibody titre by enzyme immunoassay. Samples were collected until individuals resumed cyclic ovarian activity. All mares showed suppression of cyclic ovarian activity by clinical examination and serum progesterone concentration (SPC) ≤ 1 nmol/l by Day 70 and 92.2% resumed cyclic activity by SPC at Day 720 with a mean interval = 417.8 days (s.d. ± 23.9; range 232-488 days, median 344 days). A significant age effect (P = 0.028) on the interval, but not on GnRH-antibody titre response, was observed between the yo...Continue Reading

References

Nov 5, 1997·Australian Veterinary Journal·U TshewangT E Trigg
May 22, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A M DalinL Malmgren
Jul 24, 2004·Animal Reproduction Science·T A E Stout, B Colenbrander
Oct 24, 2009·Journal of Reproductive Immunology·J F KirkpatrickR Lyda

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Citations

Dec 23, 2017·Asian-Australasian Journal of Animal Sciences·Yan-Guo HanBirhanu Tesema
Sep 15, 2020·Equine Veterinary Journal·Daphne BehrendtHarald Sieme
Jan 20, 2021·Australian Veterinary Journal·C J JoonèJ Cavalieri
Sep 4, 2021·Zoo Biology·Franz SchwarzenbergerBetina Venshøj
Jul 20, 2021·The Journal of Veterinary Medical Science·Keisuke KawaseShun-Ichi Shiihara

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