PMID: 6172389Aug 15, 1981Paper

Reversibility of the transformed and neoplastic phenotype. I. Progressive reversion of the phenotype of X-ray-transformed C3H/10T1/2 cells under prolonged treatment with interferon

International Journal of Cancer. Journal International Du Cancer
D Brouty-Boyé, I Gresser

Abstract

X-ray transformed mouse C3H/10T1/2 cells were cultivated and passaged in the continuous presence of partially purified mouse interferon. This prolonged interferon treatment resulted in a stepwise progressive reversion of the transformed phenotype to the non-transformed phenotype. Thus interferon-treated cells displayed an epithelioid morphology, grew to a lower cell density, and were no longer tumorigenic. Reversion to the non-transformed phenotype was, however, stable only as long as interferon was continuously present in the culture medium. When interferon was removed, the cells "back reverted" to the transformed phenotype. Our results suggest that interferon induced a reversion of the transformed phenotype in the entire cell population rather than a selection of an interferon resistant cell population. C-type viral particles and significant levels of reverse transcriptase were present in transformed cells, but neither present in the parental 10T1/2 cells nor in interferon-treated cells. When interferon was removed form the culture medium, viral particles and reverse transcriptase activity were again detected. It is possible, therefore, that interferon induces reversion through its antiviral activity, or that it induces rever...Continue Reading

References

Aug 18, 1975·Biochemical and Biophysical Research Communications·J C ChermannC Jasmin
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I GresserE De Maeyer
Aug 1, 1979·International Journal of Cancer. Journal International Du Cancer·D Brouty-BoyéC Baldwin
Aug 1, 1979·International Journal of Cancer. Journal International Du Cancer·D Brouty-BoyéC Baldwin
Dec 1, 1977·Cellular Immunology·I Gresser
Apr 1, 1977·Journal of the National Cancer Institute·A Fuse, T Kuwata
Feb 1, 1974·Journal of the National Cancer Institute·I GresserD Brouty-Boyé
Jul 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·M G ToveyI Gresser
Feb 1, 1981·Journal of Interferon Research·M F BourgeadeC Chany
Oct 15, 1980·International Journal of Cancer. Journal International Du Cancer·D Brouty-BoyéJ Folkman
Nov 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·I GRESSER

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Citations

Jul 1, 1990·Cancer Metastasis Reviews·H Rubin
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·H Kirchner
Oct 1, 1987·The American Journal of Medicine·L BonomoD Caccavo
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D SergiescuC Chany
May 1, 1992·Journal of Interferon Research·J Wybier-Franqui, D Brouty-Boyé
Oct 1, 1993·Journal of Interferon Research·O López OcejoP López Saura
Mar 1, 1994·International Journal of Cancer. Journal International Du Cancer·D Brouty-BoyéR Beaupain
Jan 1, 1996·Cancer Investigation·D V Kalvakolanu, E C Borden
Mar 1, 1984·Annales d'immunologie·F VignauxI Gresser
Jan 21, 1984·Journal of Theoretical Biology·J A Scott
Apr 1, 1985·European Journal of Cancer & Clinical Oncology·D Brouty-BoyéI Gresser
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·F BelardelliM T Maunoury
Jan 16, 1985·Biochemical and Biophysical Research Communications·D SamidR M Friedman
Jun 26, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Le Quoc TuanRyoichi Kuboi
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I Gresser
Feb 16, 1999·Journal of Surgical Oncology·R P HuangA L Boynton
Jan 1, 1986·CRC Critical Reviews in Biochemistry·M Rubinstein, P Orchansky
Jan 1, 1986·Medical Oncology and Tumor Pharmacotherapy·I Gresser

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