Reversible aberration of neurogenesis affecting late-stage differentiation in the hippocampal dentate gyrus of rat offspring after maternal exposure to manganese chloride

Reproductive Toxicology
Takumi OhishiMakoto Shibutani

Abstract

To examine the effects of developmental manganese (Mn)-exposure on hippocampal neurogenesis, pregnant rats were treated with MnCl(2)·4H(2)O in the diet at 32, 160 or 800 ppm from gestation day 10 to day 21 after delivery. Serum concentrations of thyroid-related hormones were examined in offspring exposed to MnCl(2)·4H(2)O at 800 or 1600 ppm. Immunohistochemical analysis revealed increased doublecortin-positive cells in the subgranular zone of the dentate gyrus on postnatal day (PND) 21 following exposure to MnCl(2)·4H(2)O at 800 ppm, indicating an increase of type-3 progenitor or immature granule cells. Reelin-positive cells, suggestive of γ-aminobutyric acid-ergic interneurons in the dentate hilus, also increased at 800 ppm on PND 21. Brain Mn concentrations increased in offspring on PND 21 at 160 and 800 ppm, whereas brain concentrations in the dams were unchanged. Serum concentrations of triiodothyronine and thyroxine decreased at 800 and 1600 ppm, whereas thyroid-stimulating hormone increased only after exposure at 800 ppm. All changes disappeared on PND 77. Thus, maternal exposure to MnCl(2)·4H(2)O at 800 ppm mildly and reversibly affects neurogenesis targeting late-stage differentiation in the hippocampal dentate gyrus of...Continue Reading

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Citations

Apr 19, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hirotoshi AkaneMakoto Shibutani
Jun 14, 2016·Neurotoxicology·Nancy L Parmalee, Michael Aschner
Mar 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherleen Xue-Fu AdamsonWei Zheng

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