PMID: 11606176Oct 19, 2001Paper

Reversible amnesia in a Type 1 diabetic patient and bilateral hippocampal lesions on magnetic resonance imaging (MRI)

Diabetic Medicine : a Journal of the British Diabetic Association
X HolemansJ F Vanderijst

Abstract

Intensive insulin therapy of Type 1 diabetes limits its chronic complications, but is associated with an increased risk of severe hypoglycaemia and its neuroglycopenic consequences. Case report. A 24-year-old male with 15 years' history of Type 1 diabetes, who was missing for 48 h, was found at home in ketoacidosis coma. Intensive care permitted a rapid improvement revealing an unexpected severe anterograde amnesia, confirmed by neuropsychological testing. MRI performed 4 days after admission showed abnormal bilateral hyperintensity signals on T2-weighted images in the hippocampus. Three months later, the patient had nearly completely recovered and resumed work. MR images and neuropsychological testing returned to normal. The most likely course of events favours an initial prolonged hypoglycaemic coma following insulin overdose. The hippocampal injury may be a result of hypoglycaemia. Neuropsychological testing and MRI abnormalities were completely reversible. This case underlines the potential risks of intensive insulin therapy.

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Citations

Jan 10, 2009·Cellular and Molecular Neurobiology·Remya RobinsonC S Paulose
Aug 26, 2006·Nature Clinical Practice. Neurology·Elisabeth A NorthamFergus J Cameron
Jan 22, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·B A KirchhoffT Hershey
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Dec 22, 2014·Acta Diabetologica·S FredheimUNKNOWN Danish Society for Diabetes in Childhood and Adolescence
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Sep 9, 2016·Applied Neuropsychology. Child·Mohamed Abo-El-AsrarKarim Abdel Aziz
Sep 20, 2016·British Journal of Hospital Medicine·Catrin Cox, Andrew J Larner
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Apr 13, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Shung-Lon LaiShun-Sheng Chen
Jun 15, 2011·Journal of Athletic Training·Jocelyn R Gravlee, John J Barrett
Nov 17, 2019·Acta neurologica Belgica·M A Ruiz Yanzi, L Alessandro
Nov 13, 2020·Advances in Nutrition·Elizabeth LedgerRobert H J Bandsma

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