Reversible blindness resulting from optic chiasmitis secondary to systemic lupus erythematosus

Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
L P FrohmanL Wolansky

Abstract

To report the diagnosis, radiologic findings, and therapy of a 51-year-old female with systemic lupus erythematosus (SLE) who, while on hydroxychloroquine maintenance therapy, presented with a junctional scotoma indicative of chiasmal disease. This visual loss developed after she had been tapered off corticosteroids. An interventional case report of a female that was given acute therapy with 1-gram daily of intravenous methylprednisolone sodium succinate for 5 days, followed by maintenance methotrexate and a slow taper of oral prednisone. Magnetic resonance imaging (MRI) scans, visual acuity, color vision, and threshold visual fields were performed. The MRI scan showed chiasmal involvement, which may occur in SLE in absence of any other evidence of systemic activity. Therapy led to visual function returning to 20/20 OD and 20/20 OS, with normal Ishihara plates OU and only minimal paracentral depressions OU. She has been able to be weaned off prednisone while on methotrexate maintenance. Chiasmal involvement may occur in SLE in absence of any other evidence of systemic activity. Maintenance with hydroxychloroquine may not be adequate to prevent this rare cause of visual loss in SLE. Aggressive therapy of chiasmal involvement in ...Continue Reading

References

Mar 1, 1989·Clinical Rheumatology·A A DrososH M Moutsopoulos
Apr 1, 1986·Archives of Ophthalmology·D A JabsM B Stevens
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester

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Citations

Feb 21, 2008·Journal of Neurology·Takashi IriokaHidehiro Mizusawa
Dec 31, 2002·Survey of Ophthalmology·Dan Milea, Phuc LeHoang
Aug 15, 2003·Neurologic Clinics·Timothy Murtha, Steven F Stasheff
Apr 24, 2014·Journal of Ophthalmology·Maria M ChoudharyCareen Y Lowder
May 3, 2014·Current Neurology and Neuroscience Reports·Valerie A Purvin, Aki Kawasaki
Dec 13, 2012·Autoimmunity Reviews·Remco K M A C LuijtenRonald H W M Derksen
May 16, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Desmond Kidd
Nov 13, 2008·Current Opinion in Ophthalmology·John B Davies, Prabakar Kumar Rao
Dec 3, 2015·International Ophthalmology Clinics·Rod Foroozan
Nov 19, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Floyd A Warren
Jun 11, 2021·Neuro-ophthalmology·Glauco Batista AlmeidaMário Luiz Ribeiro Monteiro

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