PMID: 18421190Apr 19, 2008Paper

Reversible bone marrow dysplasia in patients with systemic lupus erythematosus

Internal Medicine
Yumiko OkaHideo Harigae

Abstract

Several reports of bone marrow dysplasia in patients with systemic lupus erythematosus (SLE) have been published. However, the reports are restricted primarily to descriptions of the erythroid lineage; no follow-up studies have been reported, and the clinical significance of the dysplasias is unknown. Therefore, in the present study, the dysplasias noted in bone marrow aspirates obtained from SLE patients were characterized. The smears of bone marrow aspirates obtained from 17 SLE patients who had bone marrow aspiration due to cytopenia (WBC < 1,500/microl, or Hb < 10.5 g/dl, or platelet count < 10 x 10(4)/microl) were examined retrospectively. Of the 17 patients, 4 had a repeat bone marrow aspiration during follow-up. Clinical and laboratory data were obtained from the medical records. Of the 17 SLE patients, 12 had dysplasias, including: erythroid cell multinuclearity (trinuclear or more) (5 patients), megaloblastoid changes (4), pseudo-Pelger abnormalities (6), annular nuclear myeloid cells (2), separated nuclear megakaryocytes (4), and micromegakaryocytes (5). In the 4 patients who had follow-up bone marrow aspiration, these dysplasias were correlated with disease activity; some abnormalities disappeared with remission of S...Continue Reading

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Citations

Jul 3, 2013·Archives of Pathology & Laboratory Medicine·Kristin E HuntKathryn Foucar
Dec 1, 2013·Surgical Pathology Clinics·Dita Gratzinger, Peter L Greenberg
Aug 10, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Luci Maria Santana DusseMaria das Graças Carvalho
Aug 20, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andréia Maria Braz MoreiraLuci Maria Sant Ana Dusse
Aug 24, 2010·Histopathology·Roos J Leguit, Jan G van den Tweel
Nov 1, 2011·American Journal of Hematology·Aleksandra PaligaRuth Padmore
Aug 3, 2016·Disease Models & Mechanisms·Namrata SinghMichael F Denny
Aug 27, 2014·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Tomonori Ishii
Oct 23, 2020·Modern Rheumatology Case Reports·Tansri WibowoKeiji Maeda

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