Reversible brain MRI changes in acyclovir neurotoxicity

Bone Marrow Transplantation
M E BlohmS Burdach

Abstract

This case report shows reversible brain MRI changes probably associated with acyclovir toxicity. So far, neuroimaging in acyclovir toxicity had been negative or uninformative. A 12-year-old girl developed focal secondary generalizing epileptic fits following 4 weeks of prophylactic administration of acyclovir (3 x 10 mg/kg body weight/day i.v.) on day +22 after allogeneic peripheral blood stem cell transplantation for CML. Infective causes were excluded. Brain MRI demonstrated multiple gadolinium-enhancing areas with impairment of the blood-brain barrier in cortical and subcortical regions. Clinical symptoms and neuroimaging pathology resolved completely within 9 days of acyclovir withdrawal.

Citations

Apr 15, 2003·Neurologic Clinics·Hendrikus G J Krouwer, Eelco F M Wijdicks
Jul 9, 2013·Critical Care Clinics·Andreas H Kramer
Sep 2, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Sphamandla NtshangaseSooraj Baijnath
Jul 31, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tess E WallaceSimon K Warfield
Jan 1, 2000·Annales Françaises D'anesthèsie Et De Rèanimation·M Da ConceiçaoR Pitti
Jun 20, 2021·Journal of Clinical Pharmacy and Therapeutics·David Brandariz-NuñezIsabel Martín Herranz

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