Reversible cardiac hypertrophy induced by PEG-coated gold nanoparticles in mice

Scientific Reports
Chengzhi YangZijian Li

Abstract

Gold nanoparticles (GNPs) are attracting more and more attention for their great potential value in biomedical application. Currently, no study has been reported on the chronic cardiac toxicity of GNPs after repeated administration. Here we carried out a comprehensive evaluation of the chronic cardiac toxicity of GNPs to the heart. Polyethylene glycol (PEG) -coated GNPs at three different sizes (10, 30 and 50 nm) or PBS was administrated to mice via tail vein for 14 consecutive days. Then the mice were euthanized at 2 weeks, 4 weeks or 12 weeks after the first injection. The accumulation of GNPs in the mouse heart and their effects on cardiac function, structure, fibrosis and inflammation were analysized. GNPs with smaller size showed higher accumulation and faster elimination. None of the three sizes of GNPs affected cardiac systolic function. The LVIDd (left ventricular end-diastolicinner-dimension), LVMass (left ventricular mass) and HW/BW (heart weight/body weight) were significantly increased in the mice receiving 10 nm PEG-GNPs for 2 weeks, but not for 4 weeks or 12 weeks. These results indicated that the accumulation of small size GNPs can induce reversible cardiac hypertrophy. Our results provide the basis for the furth...Continue Reading

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Citations

Nov 2, 2018·Canadian Journal of Physiology and Pharmacology·Aiju TianZijian Li
Jul 22, 2018·Scientific Reports·Jingwen ZhangAiqun Ma
Aug 30, 2019·International Journal of Toxicology·Olusola B AdewaleSaartjie Roux
Jun 10, 2021·Pharmacology Research & Perspectives·Edwin Coleridge S NaiduOnyemaechi Okpara Azu
Jul 3, 2021·Pharmaceutics·Sabrina Sepúlveda-RivasJavier O Morales
Dec 16, 2020·ACS Biomaterials Science & Engineering·Suliman KhanMojtaba Falahati

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Methods Mentioned

BETA
transmission electron microscopy
PCR
enzyme-linked immunosorbent assay
ELISA
protein assay

Software Mentioned

GraphPad
Visualsonics
Prism

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