Reversible disruption of pre-pulse inhibition in hypomorphic-inducible and reversible CB1-/- mice.

PloS One
Maria Franca MarongiuMaria Serafina Ristaldi

Abstract

Although several genes are implicated in the pathogenesis of schizophrenia, in animal models for such a severe mental illness only some aspects of the pathology can be represented (endophenotypes). Genetically modified mice are currently being used to obtain or characterize such endophenotypes. Since its cloning and characterization CB1 receptor has increasingly become of significant physiological, pharmacological and clinical interest. Recently, its involvement in schizophrenia has been reported. Among the different approaches employed, gene targeting permits to study the multiple roles of the endocannabinoid system using knockout ((-/-)) mice represent a powerful model but with some limitations due to compensation. To overcome such a limitation, we have generated an inducible and reversible tet-off dependent tissue-specific CB1(-/-) mice where the CB1R is re-expressed exclusively in the forebrain at a hypomorphic level due to a mutation (IRh-CB1(-/-)) only in absence of doxycycline (Dox). In such mice, under Dox(+) or vehicle, as well as in wild-type (WT) and CB1(-/-), two endophenotypes motor activity (increased in animal models of schizophrenia) and pre-pulse inhibition (PPI) of startle reflex (disrupted in schizophrenia) w...Continue Reading

References

Mar 5, 1998·Journal of Neuroscience Research·D A PettitG A Cabral
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·A ZimmerT I Bonner
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·H SteinerA Zimmer
Jul 19, 2000·Developmental Biology·K Y Gregg, E C Cox
Nov 21, 2000·Current Opinion in Neurobiology·I M Mansuy, H Bujard
Jan 17, 2002·Functional & Integrative Genomics·S A RifkinJ Kim
Feb 12, 2002·Nature Reviews. Genetics·Maja Bućan, Ted Abel
Oct 31, 2002·Psychopharmacology·Renee S MartinDavid A Lowe
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Seungkirl AhnRobert J Lefkowitz
Jun 26, 2003·Nucleic Acids Research·Pauline C Ng, Steven Henikoff
Aug 16, 2003·Molecular Pharmacology·Helena AnderssonChen-Ni Chin
Oct 4, 2003·Science·Giovanni MarsicanoBeat Lutz
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Daniel T MaloneDavid A Taylor
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin K YeeJoram Feldon
Jun 24, 2004·The Journal of Biological Chemistry·Christophe LeterrierZsolt Lenkei
Sep 9, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea GiuffridaDaniele Piomelli
Nov 20, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Fernando Rodríguez de FonsecaMiguel Navarro
Apr 21, 2005·European Journal of Pharmacology·Fabrício A Moreira, Francisco S Guimarães
Jul 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agnes L BodorTamás F Freund
Oct 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·A Bilkei-GorzoA Zimmer
Oct 28, 2005·Current Pharmaceutical Design·Olga Valverde
Jul 6, 2006·Pharmacology, Biochemistry, and Behavior·Hiroshi NagaiMichihiro Fujiwara
Jan 26, 2007·Molecular Pharmacology·Laura M Bohn
Feb 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martina BallmaierPierFranco Spano
May 8, 2007·Biological Psychiatry·Stella G GiakoumakiSophia Frangou
Jul 3, 2007·Psychopharmacology·Marco BortolatoFrancesco Marrosu
Aug 3, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nora HamdaniPhilip Gorwood
Sep 21, 2007·Neuroscience Letters·Jürgen SeifertManfred Stuhrmann
Feb 13, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raphael Rozenfeld, Lakshmi A Devi
Mar 8, 2008·Learning & Memory·Shahnaz Christina AzadGerhard Rammes
Jun 21, 2008·Clinical and Experimental Pharmacology & Physiology·Natasha L GrimseyMichelle Glass
Apr 29, 2009·Behavioural Brain Research·Susan B PowellMark A Geyer

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Citations

Apr 22, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonio Ortega-ÁlvaroJorge Manzanares
Nov 14, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ayelet KaminitzAbraham Weizman
May 21, 2021·Neurobiology of Disease·Zhaohong QinHsiao-Huei Chen
Jun 27, 2021·Autism Research : Official Journal of the International Society for Autism Research·William FykeSusanna Pietropaolo

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Datasets Mentioned

BETA
U89933

Methods Mentioned

BETA
transgenic
PCR
biopsy
protein folding

Software Mentioned

ImagePro Plus
Graph Pad Prism
Digiscan Animal Activity Analyzer

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