Reversible Electroporation-Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With 89 Zr-Labeled Reporter Nanoparticles

Molecular Imaging
Govindarajan SrimathveeravalliThomas Reiner

Abstract

Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle (89Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered 89Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of 89Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of 89Zr-NRep in tumors. 89Zr-NRep and DOX uptake correlated well in both electroporated and control tumors at all experimental time points. Electroporation accelerated 89Zr-NRep and DOX deposition into tumors and increased DOX dosing. Reversible electroporation-related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with 89Zr-NRep.

References

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Citations

May 29, 2019·Journal of Labelled Compounds & Radiopharmaceuticals·Renata MikolajczakSuzanne E Lapi
Jan 26, 2021·Chemical Society Reviews·Juan PellicoRafael T M de Rosales
Apr 3, 2021·Frontiers in Oncology·Marina Santiago FrancoMônica Cristina Oliveira

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Methods Mentioned

BETA
transfection
imaging techniques

Software Mentioned

MatLab
ASIPro VMTM

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