PMID: 2501552Apr 3, 1989Paper

Reversible germ cell toxicity following aggressive chemotherapy in patients with testicular tumors: results of a prospective study

Klinische Wochenschrift
E D KreuserH Heimpel

Abstract

The impact of aggressive chemotherapy on reproductive and endocrine gonadal function was prospectively studied in 44 patients with germ cell tumors. Diagnostic procedures to determine gonadal toxicity consisted of hormone determinations, semen analyses, interviews with a standardized questionnaire, and gonadal histology. After chemotherapy all patients showed elevated serum levels of follicle-stimulating hormone (FSH) and azoospermia due to germ cell and stem cell loss. Recovery of spermatogenesis, as indicated by normalization of serum FSH levels and sperm density, occurred in 77% of the patients 25-60 months after cessation of chemotherapy. In all patients serum testosterone and luteinizing hormone (LH) values remained within normal limits after therapy indicating resistance of Leydig cells to cytotoxic drugs. Three patients fathered four healthy children after completion of chemotherapy. These data suggest significant reproductive dysfunction in all men treated for germ cell tumors. However, most patients showed late and complete recovery of spermatogenesis. In contrast, endocrine gonadal function was unaffected after chemotherapy in all patients. FSH and LH are feasible markers to assess drug-induced gonadal toxicity.

References

Mar 1, 1986·European Journal of Cancer & Clinical Oncology·E D KreuserW Schreml
Mar 1, 1985·Annals of Internal Medicine·B EttingerC E Cann
Oct 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S P LeitnerD Bajorunas
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·E D KreuserH Heimpel
Apr 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E D KreuserH Heimpel
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
Jan 1, 1986·Cell and Tissue Research·P AmatA Martín
May 1, 1974·The Journal of Clinical Endocrinology and Metabolism·D M de KretserB Hudson
Mar 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R E DrasgaE E Stevens
Jan 1, 1983·Monographs on Endocrinology·D M de KretserW J Bremner
Jul 29, 1983·Deutsche medizinische Wochenschrift·M RisterE Gladtke
Apr 1, 1981·The Journal of Clinical Endocrinology and Metabolism·R S Scott, H G Burger
Apr 1, 1982·International Journal of Andrology·S D FossåA Aakvaag

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Citations

Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K P Dieckmann, V Loy
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M L Meistrich
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·M DeSantisJ Pont
May 21, 2003·International Journal of Andrology·Marvin L Meistrich, Gunapala Shetty
Jul 7, 2005·British Journal of Cancer·R A HuddartD P Dearnaley
Mar 28, 2009·Pediatric Blood & Cancer·Marvin L Meistrich
Nov 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Zhen ZhangMarvin L Meistrich
Apr 1, 1993·International Journal of Andrology·K P Dieckmann, V Loy
Mar 14, 2003·Journal of Andrology·Marvin L Meistrich, Gunapala Shetty
Jun 3, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Marvin L Meistrich, Gunapala Shetty
Nov 21, 2009·Reproductive Biology and Endocrinology : RB&E·Fozia J ShahKristian Almstrup

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