Reversible hearing impairment induced by lithium in the guinea pig

Neuroreport
K C HornerY Cazals

Abstract

Lithium salts remain one of the most widely used treatments for depressive illness. The mechanisms involved probably include reduction in free inositol. Visual perceptive disturbances can be a side effect of the treatment. We report here for the first time that chronic lithium treatment in the guinea pig induces a predominantly low frequency hearing loss and, in the longer term, loss of sensitivity is observed across the whole audiogram. The changes are reversed when treatment is arrested. The observations could be accounted for, at least partially, by a lithium-induced perturbation of the phosphoinositide cascade within the inner ear.

References

May 22, 1991·Proceedings. Biological Sciences·G D Housley, J F Ashmore
Dec 1, 1987·Hearing Research·J Schacht, H P Zenner
Apr 1, 1987·Journal of Neurochemistry·S K Fisher, B W Agranoff
Jan 1, 1986·Neuropsychobiology·D Kropf, B Müller-Oerlinghausen
Nov 1, 1985·American Journal of Otolaryngology·H Spoendlin
Jul 1, 1993·Drugs·M Peet, J P Pratt
Sep 1, 1996·Hearing Research·P S Guth, C H Norris
Jan 1, 1989·Neurochemistry International·T Ono, J Schacht

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Citations

Sep 28, 1998·The European Journal of Neuroscience·K C HornerY Cazals
Dec 3, 1998·Pharmacology & Toxicology·M SharifzadehN Aghaebrahimi
Sep 16, 2011·Cochlear Implants International·Jonathan H K KongNeil Donnelly

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