Reversible hepatotoxicity of paroxetine in a patient with major depression

Pharmacopsychiatry
C HelmchenU Hegerl

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are becoming widely used because of their favorable side-effect profile and their safety in overdose. We report about a patient with recurring major depression (DSM-IIIR) who was treated with paroxetine and developed a severe hepatotoxic reaction, which was reversed after withdrawal of the drug. Individual, patient-related causes for this side-effect were not found. To our knowledge, this is the first published case of a probably paroxetine-induced severe hepatotoxicity. Hepatotoxicity should be taken into account as a rare complication that may occur not only with tricyclic antidepressants (TCAs) but also with SSRIs.

Citations

Nov 3, 2001·Journal of Hepatology·L Fartoux-HeymannA Mallat
May 29, 2002·Alimentary Pharmacology & Therapeutics·M R KrausM Scheurlen
Jan 23, 1999·Journal of Clinical Gastroenterology·J F CadranelM Biour
Jul 16, 1999·Mayo Clinic Proceedings·Q CaiJ P Kirchner
Jun 21, 2005·International Journal of Clinical Practice·O ColakogluZ Akpinar
Dec 29, 2000·Journal of the American Geriatrics Society·M M VerricoA L Towers
Jul 5, 2007·The Annals of Pharmacotherapy·Kevin P DeSanty, Celene M Amabile
Aug 22, 2001·The American Journal of Gastroenterology·M OdehA Oliven
Aug 5, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Carmen FerrajoloUNKNOWN DILI-IT Study Group
Aug 9, 2003·Expert Opinion on Drug Safety·M Isabel LucenaAlfonso Velasco
Jan 6, 2021·Archives of Toxicology·Nevena Todorović VukotićSnežana B Pajović

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