Reversible impairment of coronary flow reserve in acute myocarditis

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Joerg KellermairClemens Steinwender

Abstract

Acute myocarditis is accompanied by an impaired coronary microcirculation. These microcirculatory disturbances are not well defined, and data are derived from complex invasive measurements. Therefore, this study aimed to evaluate the inflammation-induced microcirculatory dysfunction including its reversibility and association with markers of inflammation severity (extent of LGE on CMR imaging and laboratory markers of myocardial necrosis) using the noninvasive technique of echocardiographic CFR measurement. Patients (n = 14) with clinically suspected acute myocarditis in the absence of coronary artery disease were prospectively enrolled, and echocardiographic CFR was determined by measuring peak diastolic coronary blood flow velocity at rest (PDV1) and under adenosine-induced hyperemia (PDV2) at baseline and 3-month follow-up. Eight of 14 (57.1%) patients showed an impaired baseline CFR (PDV2/PDV1 < 2). These patients were characterized by higher levels of cardiac troponin T (0.55 ± 0.39 vs 0.18 ± 0.08; P = 0.008) and larger areas of LGE on CMR. At 3-month follow-up, CFR was normal in all patients. A reversibly impaired coronary microcirculation is a frequent finding in acute myocarditis and is associated with markers of inflam...Continue Reading

References

Jul 1, 1989·American Heart Journal·M A Silver, D Kowalczyk
Oct 1, 1993·Journal of the American College of Cardiology·M J Sole, P Liu
Apr 11, 2000·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·H E LimY M Ro
Oct 10, 2002·The American Journal of Cardiology·Maurizio GalderisiOreste de Divitiis
Nov 25, 2003·Cardiology·Rolf Michael KleinBodo Eckehard Strauer
Feb 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Antti SarastePekka Saukko
Feb 26, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patrick Meimoun, Christophe Tribouilloy
Apr 29, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Johnny VegsundvågTorstein Hole
Sep 24, 2011·International Journal of Inflammation·Norifumi Takeda, Ichiro Manabe
Dec 4, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Amanda J LeblancJudy M Muller-Delp
Jul 5, 2013·European Heart Journal·Alida L P CaforioUNKNOWN European Society of Cardiology Working Group on Myocardial and Pericardial Diseases
Mar 1, 2014·Circulation Research·Marieke RienksStephane Heymans
Dec 5, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xiao-Zhi ZhengWen-Zhang Zha
Jan 6, 2016·World Journal of Cardiology·Giuseppe Barletta, Maria Riccarda Del Bene

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