PMID: 11927687Apr 3, 2002Paper

Reversible impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation

The Journal of Physiology
Hideki SaitoT Takewaki

Abstract

The effects of hibernation on endothelium-dependent vasodilatation were investigated in the golden hamster carotid artery, paying special attention to hibernating body temperature (10 degrees C). To record mechanical and electrical membrane responses, we applied pharmacological (organ bath) and electrophysiological (microelectrode) techniques, using acetylcholine (ACh; 0.001-100 microM) and ATP (0.01-1000 microM) for endothelium-dependent vasodilatation and sodium nitroprusside (SNP; 0.05-10 microM) for endothelium-independent vasodilatation. At 34 degrees C, ACh, ATP and SNP each induced a relaxation or a hyperpolarization, and these responses were similar in all the preparations from control and hibernated animals. At 10 degrees C, on the other hand, ACh-induced relaxations and hyperpolarizations were reduced to approximately 35 % and 50 % of the euthermic level in controls and 1 % and 4 % of the euthermic level in hibernated animals, respectively. In contrast, at 10 degrees C, ATP induced only a contraction or depolarization in all preparations with no significant difference between control and hibernated animals. SNP-induced relaxations and hyperpolarizations obtained at 34 degrees C were not attenuated by cooling to 10 deg...Continue Reading

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Citations

Jul 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Seiji MiyazawaTadashi Takewaki
Apr 23, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P G OsborneM Hashimoto
Feb 23, 2013·The Journal of Experimental Biology·Stuart EggintonDavid Hauton

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