PMID: 2500904Jul 1, 1989Paper

Reversible impairment of gonadotropin secretion in critical illness. Observations in postmenopausal women

Archives of Internal Medicine
S S GebhartD Sgoutas

Abstract

Gonadotropin levels were measured in 65 postmenopausal women admitted to the intensive care unit. Sixteen patients (25%) were hypogonadotropic as measured by luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels of 5 IU/L or less, and only 20 patients (31%) were found to have gonadotropin levels within the expected postmenopausal range (greater than or equal to 30 IU/L). No significant differences in prolactin or free thyroxine levels were found, but the cortisol level was higher and the total thyroxine level lower in the hypogonadotropic group. The patients in the hypogonadotropic group also seemed more seriously ill, with a longer duration of hospitalization, an increased total number of days in the intensive care unit, an increased number of days in the intensive care unit before gonadotropin sampling, a higher incidence of parenteral hyperalimentation, lower serum albumin levels, and higher mortality. Stimulation of the gonadotropin-releasing hormone performed on 10 patients showed a blunted response in patients with baseline LH and FSH levels of 10 IU/L or less. Of 10 patients followed up sequentially, 6 showed a rise in gonadotropin levels that paralleled recovery, 1 died with low gonadotropin levels, and...Continue Reading

Citations

Dec 29, 1995·Annals of the New York Academy of Sciences·M ReinckeB Allolio
Feb 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Tarek SharsharUNKNOWN Groupe de Réflexion et d'Etude des Neuromyopathies En Réanimation
Mar 25, 2010·Intensive Care Medicine·Tarek SharsharKathleen Laborde

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