Reversible inactivation of monkey superior colliculus. I. Curvature of saccadic trajectory

Journal of Neurophysiology
H Aizawa, R H Wurtz

Abstract

The neurons in the intermediate layers of the monkey superior colliculus (SC) that discharge before saccadic eye movements can be divided into at least two types, burst and buildup neurons, and the differences in their characteristics are compatible with different functional contributions of the two cell types. It has been suggested that a spread of activity across the population of the buildup neurons during saccade generation may contribute to the control of saccadic eye movements. The influence of any such spread should be on both the horizontal and vertical components of the saccade because the map of the movement fields on the SC is a two-dimensional one; it should affect the trajectory of saccade. The present experiments used muscimol injections to inactivate areas within the SC to determine the functional contribution of such a spread of activity on the trajectory of the saccades. The analysis concentrated on saccades made to areas of the visual field that should be affected primarily by alteration of buildup neuron activity. Muscimol injections produced saccades with altered trajectories; they became consistently curved after the injection, and successive saccades to the same targets had similar curvatures. The curved s...Continue Reading

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Citations

Apr 19, 2002·Annals of the New York Academy of Sciences·David M WaitzmanStacy DePalma
Dec 4, 2002·Nature Reviews. Neuroscience·David L Sparks
Mar 11, 2003·Nature Neuroscience·André BergeronDaniel Guitton
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May 21, 2010·The Quarterly Journal of Experimental Psychology : QJEP·Frouke Hermens, Robin Walker
Apr 5, 2011·Annual Review of Neuroscience·Neeraj J Gandhi, Husam A Katnani
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Jun 19, 2012·Journal of Glaucoma·Cédric LamirelJean Lorenceau
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Jun 9, 2017·Journal of Neurophysiology·Geoffrey MegardonPetroc Sumner
Sep 12, 2019·Frontiers in Behavioral Neuroscience·Nico A FliermanAleksandra Badura
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Oct 12, 2007·Journal of Neurophysiology·Takuro Ikeda, Okihide Hikosaka

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