Reversible inactivation of monkey superior colliculus. II. Maps of saccadic deficits

Journal of Neurophysiology
C QuaiaR H Wurtz

Abstract

Neurons in the superior colliculus (SC) are organized as maps of visual and motor space. The companion paper showed that muscimol injections into intermediate layers of the SC alter the trajectory of the movement and confirmed previously reported effects on latency, amplitude, and speed of saccades. In this paper we analyze the pattern of these deficits across the visual field by systematically comparing the magnitude of each deficit throughout a grid of targets covering a large fraction of the visual field. We also translate these deficits onto the SC map of the visual/movement fields to obtain a qualitative estimate of the extent of the deficit in the SC. We found a consistent pattern of substantially increased saccadic latency to targets in the contralateral visual hemifield, accompanied by slight and inconsistent increases and decreases for saccades to the ipsilateral hemifield. The initial and peak speed of saccades was reduced after the injection. The postinjection amplitude of the saccades were either hypometric or normometric, but rarely hypermetric. Although errors in the initial direction of the postinjection saccades were small, they consistently formed a simple pattern: an initial direction with minimal errors (a nu...Continue Reading

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Citations

Apr 19, 2002·Annals of the New York Academy of Sciences·Lance M Optican, Christian Quaia
Jun 15, 2004·Nature Neuroscience·Robert M McPeek, Edward L Keller
Sep 28, 2004·Experimental Brain Research·Doug P HanesRobert H Wurtz
Apr 28, 2006·Journal of Neurophysiology·C Kip RodgersMartin Paré
Oct 27, 2016·Journal of Neurophysiology·Iman Haji-AbolhassaniHenrietta L Galiana
Sep 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko Kojima, Robijanto Soetedjo
Aug 13, 1999·Journal of Neurophysiology·C QuaiaL M Optican
Apr 14, 2005·Annals of the New York Academy of Sciences·Lance M Optican
Apr 21, 2006·Journal of Neurophysiology·Eugene McSorleyRobin Walker
Mar 4, 2003·Journal of Neurophysiology·Robert M McPeekEdward L Keller
Sep 3, 2004·Journal of Neurophysiology·Masayuki WatanabeTadashi Isa
Sep 23, 2016·Journal of Neurophysiology·Hrishikesh M RaoMarc A Sommer
Jun 13, 2018·Neural Computation·Thomas Parr, Karl J Friston
May 30, 1998·Journal of Neurophysiology·H Aizawa, R H Wurtz
Mar 27, 2009·Journal of Neurophysiology·Rebecca A BermanRobert H Wurtz
Dec 24, 2005·Journal of Neurophysiology·H H L M Goossens, A J Van Opstal
Jul 26, 2013·Journal of Neurophysiology·A DeplanckeY Coello
Dec 4, 2002·Nature Reviews. Neuroscience·David L Sparks
Mar 11, 2003·Nature Neuroscience·André BergeronDaniel Guitton
Feb 29, 2008·Journal of Neurophysiology·Mark M G WaltonNeeraj J Gandhi
Mar 6, 2009·Journal of Neurophysiology·Pedro Cardoso-Leite, Andrei Gorea
Jun 8, 2011·The European Journal of Neuroscience·Ziad M Hafed
Sep 26, 2013·Journal of Computational Neuroscience·Pierre M DayePhilippe Lefèvre
Oct 25, 2013·Journal of Neurophysiology·Tyler R PeelBrian D Corneil
Apr 5, 2011·Annual Review of Neuroscience·Neeraj J Gandhi, Husam A Katnani
Jan 19, 2016·The European Journal of Neuroscience·A DeplanckeY Coello
Aug 9, 2003·Journal of Neurophysiology·Mark M G Walton, Lawrence E Mays
Jul 29, 2011·Journal of Neurophysiology·Luis C Populin, Abigail Z Rajala

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