PMID: 1209648Nov 1, 1975Paper

Reversible inhibition of DNA, RNA and protein synthesis in human cells by lead chloride

Toxicology
Y Skreb, V Habazin-Novak

Abstract

An acute intoxication by lead chloride (conc. 2.5 - 10(-4)M) produces a temporary reduction of macromolecular syntheses in HeLa cells growing asynchronously. The reduction is similar for DNA, RNA and proteins and differs only in the intensity. After a one-day intoxication, if the cells are put back in a fresh medium, the syntheses return to normal within 10 h. The histochemical sulphide-silver method shows that lead is present in the cells during the inhibition.

Citations

Aug 1, 1988·Archives of Toxicology·Z S al-HakkakA A Bazzaz
Nov 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J N Wu, E Tiffany-Castiglioni
Apr 1, 1983·Journal of the Neurological Sciences·J L KennedyD M Nicholls
May 1, 1982·Toxicology and Applied Pharmacology·J G PoundsJ G Shaddock
Sep 1, 1980·Mutation Research·G B GerberP Jacquet
Jul 1, 1986·Mutation Research·Z S Al-HakkakA F Hussain
Jan 1, 1990·Neurochemistry International·C A DrewG A Johnston
Dec 15, 1986·Toxicology·E Tiffany-CastiglioniG R Bratton
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D M NichollsM J Kuliszewski
Feb 1, 1980·Toxicology and Applied Pharmacology·B R BlakleyT K Mukkur
Jun 27, 2014·Archives of Environmental & Occupational Health·Zeliha KayaaltıTülin Söylemezoğlu
Jan 1, 1994·Environmental and Molecular Mutagenesis·R H LinS Y Lin-Shiau
Jan 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M MollsN Zamboglou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.