Reversible introduction of transgenes in natural populations of insects

Insect Molecular Biology
A Le Rouzic, P Capy

Abstract

The most serious challenge concerning genetically modified insects remains their invasion ability. Indeed, transgenic insects often show lower fitness than wild individuals, and the transgene does not seem able to spread through a natural population without a driving system. The use of remobilizable vectors, based on the invading properties of transposable elements, has been frequently suggested. Simulations show that this strategy can be efficient. Moreover, if the transgene is designed to use transposition machinery already present in the genome, the transgene invasion appears to be potentially reversible after a few hundred generations, leading to new experimental perspectives.

References

Dec 1, 1992·Current Opinion in Genetics & Development·M G Kidwell
Dec 1, 1988·Genetical Research·C H LangleyB Charlesworth
Jan 1, 1995·Molecular Biology and Evolution·S V Nuzhdin, T F Mackay
Jan 1, 1994·Journal of Medical Entomology·J M Ribeiro, M G Kidwell
Jul 22, 1996·Proceedings. Biological Sciences·S V NuzhdinT F Mackay
May 1, 1997·Trends in Genetics : TIG·D L HartlA R Lohe
Jan 1, 1997·Annual Review of Genetics·M Labrador, V G Corces
Sep 1, 1999·Insect Molecular Biology·P SundararajanD A O'Brochta
Dec 10, 1999·Genetical Research·L A VasilyevaV A Ratner
Jul 6, 2000·Nature·C J Coates
May 24, 2001·Molecular Genetics and Genomics : MGG·C Augé-GouillouY Bigot
Feb 8, 2002·Nature·Brian Greenwood, Theonest Mutabingwa
May 23, 2002·Science·Ronald H A Plasterk
May 25, 2002·Nature·Junitsu ItoMarcelo Jacobs-Lorena
Jun 27, 2002·Journal of Molecular Biology·Zongbin CuiPerry B Hackett
Oct 5, 2002·Science·Thomas W ScottChristophe Boëte
Oct 5, 2002·Science·Luke AlpheyFrank H Collins
Oct 5, 2002·Science·Robert A HoltStephen L Hoffman
Feb 22, 2003·Science·Flaminia CatterucciaAndrea Crisanti
Mar 20, 2003·Evolution; International Journal of Organic Evolution·Christian BiémontCristina Vieira
Sep 25, 2003·The Journal of Experimental Biology·Michael A RiehleMarcelo Jacobs-Lorena
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nic IrvinPeter W Atkinson
Feb 5, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zsuzsanna Izsvák, Zoltán Ivics
Apr 15, 2004·Genetics·Luciano A MoreiraMarcelo Jacobs-Lorena
May 6, 2004·Genetical Research·David Houle, Sergey V Nuzhdin
Jul 10, 2004·Insect Biochemistry and Molecular Biology·Zhijian Tu, Craig Coates
Aug 7, 2004·Current Biology : CB·Peter Kareiva
Mar 31, 2005·Trends in Genetics : TIG·Alejandro Sánchez-GraciaBrian Charlesworth
Sep 22, 2005·Genetical Research·Arnaud Le Rouzic, Grégory Deceliere

❮ Previous
Next ❯

Citations

May 30, 2008·Journal of Mathematical Biology·John M Marshall
Sep 6, 2007·Insect Biochemistry and Molecular Biology·Yunxin HuangFred Gould
Jun 6, 2009·Journal of Theoretical Biology·John M Marshall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.