Reversible loss of reproductive fitness in zebrafish on chronic alcohol exposure

Alcohol
Pooran Singh DewariRakesh K Mishra

Abstract

Alcoholism is one of the most prevalent diseases in society and causes significant health and social problems. Alcohol consumption by pregnant women is reported to cause adverse effects on the physical and psychological growth of the fetus. However, the direct effect of chronic alcohol consumption on reproductive fitness has not been tested. In recent years, the zebrafish (Danio rerio) has emerged as a versatile model system to study the effects of alcohol on behavior and embryonic development. We utilized the zebrafish model system to address the effect of chronic alcohol exposure (0.5% alcohol in the holding tank for 9 weeks) on reproductive capacity. We found a dramatic decrease in fecundity, measured by counting the number of eggs laid, when at least one of the parents is subject to chronic alcohol exposure. Interestingly, a 9-week alcohol withdrawal program completely restored the reproductive capacity of the treated subjects. In agreement with observations on fecundity, the chronic alcohol exposure leads to increased anxiety, as measured by the novel-tank diving assay. Conversely, the withdrawal program diminished heightened anxiety in alcohol-exposed subjects. Our results highlight the adverse effects of chronic alcohol ...Continue Reading

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Citations

Oct 13, 2017·Zebrafish·Sreeja SarasammaChung-Der Hsiao
Aug 16, 2019·Disease Models & Mechanisms·Yijie Geng, Randall T Peterson
Dec 8, 2020·Neuroscience·Jotele Fontana AgostiniAlmir Gonçalves Wanderley
Apr 28, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Luisa PonzoniMariaelvina Sala

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