PMID: 3753658Mar 15, 1986Paper

Reversible mechlorethamine-associated hearing loss in a patient with Hodgkin's disease

Cancer
G M Segal, L G Duckert

Abstract

Mechlorethamine, when administered in massive doses (0.6-1.5 mg/kg) to cancer patients in several early studies, caused severe irreversible hearing loss. There have been no reports of ototoxicity with doses of 0.4 mg/kg or less. The authors describe a 36-year-old man who developed profound sensorineural hearing loss during his first cycle of MOPP chemotherapy for Hodgkin's disease. Cyclophosphamide was substituted for mechlorethamine in subsequent cycles and his hearing deficit resolved. This is the first reported case of reversible ototoxicity associated with currently recommended doses of mechlorethamine.

References

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Citations

Oct 27, 2010·Advances in Hematology·Sean Grimm, Marc Chamberlain
Jan 6, 2006·Chemical & Pharmaceutical Bulletin·Saieed PirouzpanahHamidi Aliasghar

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